Large Animal Models: Essential Tools in Disease Research
2024-12-02 Compared to rodents and non-human primates, large animal models such as dogs and miniature pigs offer unique advantages. They provide a balance between genetic, physiological, and structural similarities to humans, while maintaining relatively low experimental costs, making them invaluable in research and medical applications. These models are particularly effective in studying cardiovascular, neurological, dermatological, […]
PDXO Model: A Significant Advancement in Precision Oncology
2024-12-02 Patient-Derived Xenograft Organoids (PDXOs) are 3D organoid models derived from patient-derived xenograft (PDX) tumor tissues. Constructed using methods similar to those employed for patient-derived organoids (PDOs), PDXOs replicate the genetic, molecular, and structural features of the original tumors with exceptional accuracy. These models surpass traditional 2D cell cultures by preserving the complex internal architecture […]
Did You Know That Medicilon Can Handle DMPK Studies?
2024-10-22 Medicilon Preclinical Pharmacokinetics Department has many professional scientists with rich theoretical knowledge and experimental experience for experimental design, implementation, bioanalysis and data analysis. Our Pharmacokinetics Lab has passed the NMPA GLP certification. Following the guiding principles of ICH, NMPA and FDA . The lab offers in vivo and in vitro pharmacokinetic tests according to […]
Medicilon’s GLP-1 New Drug R&D Service
2023-06-12 Type 2 diabetes is a progressive disease. The disease course is primarily characterized by a decline in β-cell function and worsening of insulin resistance. Therefore, various antidiabetic agents are under research and development. The hypoglycemic strategy has also shifted from “sugar control” to both “sugar control” and “heart protection”. GLP-1R agonists can improve left […]
Antibody-oligonucleotide conjugates (AOCs) —A new wave of drug conjugates
2023-05-19 Antibody-Oligonucleotide Conjugates (AOCs) represent an emerging class of functionalized antibodies that have already been used in a wide variety of applications. Combining the specific binding ability of antibodies with the vast structural and functional properties of oligonucleotides, these conjugates have found a wide variety of applications as imaging, detection and therapeutic agents. AOCs are […]
The Role of the Ames Test in Predicting the Genotoxicity of Impurity Compounds in Drugs
2023-01-05 Many impurities in drugs can produce toxic and side effects, which is a crucial factor affecting the safety and effectiveness of drugs, especially genotoxic impurities that can cause serious harm to human health with minimal exposure. Therefore, to ensure API quality and preparations, Genotoxic impurities are a class of impurities that must be paid attention […]
Aim at chemical synthesis through Ibuprofen
2023-01-02 Recently, Pfizer’s new crown-specific drug Paxlovid and the national miracle drug Ibuprofen are the most popular drugs in the medical circle. Today we will talk about the synthesis and mechanism of action of Ibuprofen, an evergreen drug! Recently, Ibuprofen has been hard to find, and it has become a well-known hard currency. Ibuprofen Ibuprofen, […]
