Bridging preclinical research & translational medicine
Preclinical Research
Preclinical research is the foundation of translational medicine, ensuring drug candidates are safe, effective, and optimized for human trials.
Better, Safer Data
The role of preclinical research in translational sciences
Preclinical research is the foundation of translational medicine, bridging laboratory discoveries and clinical applications. By integrating ADME/DMPK, pharmacodynamics (PD), and safety assessment, this process increases the likelihood of drug candidates advancing successfully to effective therapies.
At Medicilon, our integrated ADME/DMPK, pharmacodynamics (PD), and safety assessment studies deliver high-quality, regulatory-compliant data, ensuring a smooth transition from early research to clinical trials.
Early-Stage Drug Discovery
Screening and optimizing compounds with predictive ADME/DMPK and PD studies
Clinical Trial Success
Using biomarker-driven insights, PK/PD modeling, and safety assessments to minimize clinical risks.
Regulatory Submissions (IND/NDA)
Generating high-confidence preclinical data to support FDA, NMPA, and EMA approvals.
REsearch and Application
Preclinical research capabilities
Medicilon provides comprehensive preclinical research services, including pharmacokinetics, disease modeling, and drug safety evaluation, to advance translational medicine.
ADME/DMPK Studies
Understanding drug absorption, metabolism, and excretion is crucial for predicting human pharmacokinetics. Our in vitro and
in vivo ADME/DMPK services support:
Predicting Drug Behavior
- Drug Candidate Selection to identify molecules with optimal pharmacokinetics for higher clinical success.
- Drug-Drug Interaction (DDI) & Bioavailability Prediction to utilize CYP450 inhibition/induction studies.
- Dosing Strategy Refinement to leverage PBPK modeling and tissue distribution studies.
PD in Translational Science
PD studies evaluate how drugs interact with molecular targets, ensuring therapeutic effectiveness. Medicilon’s comprehensive PD services support:
Linking Drug Exposure to Efficacy
- Developing PK/PD models to integrate preclinical and clinical data.
- Using PD biomarkers to confirm target engagement in early clinical trials.
- Optimizing dose-response relationships to predict therapeutic windows.
Safety Assessment
Toxicology and safety pharmacology studies are essential for clinical success. Medicilon’s GLP safety assessments include:
Ensuring Drug Safety Before Clinical Trials
- Comprehensive toxicology studies to establish safe dosage limits.
- Safety pharmacology screening for cardiovascular, CNS, and respiratory effects.
- Genotoxicity, immunogenicity, and reproductive toxicity testing.
End to end expertise
How Medicilon powers translational medicine
Medicilon enhances translational medicine by providing human-relevant preclinical models, biomarker-driven insights, and regulatory-compliant data, ensuring drug candidates efficiently transition from research to clinical trials.
Preclinical-to-Clinical Integration
Seamless transition from discovery to IND filing.
AI & Data-Driven Decision Making
Advanced PK/PD modeling and biomarker validation.
Global Regulatory Compliance
Meeting FDA, NMPA, and EMA drug approval standards.
Focus on Human Relevance
Using advanced animal models, organ-on-a-chip, and 3D cell cultures.
cONCEPT TO ind
Why choose Medicilon for preclinical research?
Comprehensive Preclinical Research Services
Seamless transition from discovery to IND filing
Expert Scientific Team
Decades of experience in drug metabolism, safety, and efficacy studies.
Tailored Drug Development Strategies
Customized study designs for biotech and pharma clients.
State-of-the-Art Facilities
> 300,000 sqft GLP-certified labs with cutting-edge technology.
