Decoding Tumor Model：Syngeneic Models

Oncologists produce syngeneic tumor models using tissue from the same species as the test subject (i.e. mouse), whereas xenograft models require the transplantation of a tumor from a heterologous species (typically a human patient) into the mouse or other animal subject.

Syngeneic tumor models are highly effective in preclinical research for studying cancer biology, assessing therapeutic strategies, and understanding immune responses within a controlled genetic environment.

Syngeneic tumor model strategies allow for the generation of tumors comprising the full repertoire of non-malignant cell types.

Syngeneic tumor models benefit from retention of the tumor microenvironment and disease strain from the donor animal.

Therefore, the recipient's immune system is unlikely to reject the transplanted tissues.

Compared to heterogeneic models, syngeneic tumor experimentsbenefits from low cost, convenience, and ease of use.

The dawn of the era of target therapies moved the scientific community toward therapies directed against human tumor targets.

Mouse tumors, however, do not normally reflect the genetic complexity of human tumors because mouse tumors have comparatively lower mutational loads.