Cell Line Derived Xenograft (CDX) Models for Preclinical Research

Cell line-derived xenograft (CDX) models are crucial tools in cancer research.

CDX models can be grown as subcutaneous, disseminated, or orthotopic cancers in both mouse and rats.

They can also be used in humanized mouse models for evaluating immunotherapies within an intact human immune system.

CDX models have been applied to various studies, including the metastatic progression, genetic evolution, and therapeutic drug response.

Compared to patient-derived xenograft (PDX) models, CDX models offer significant advantages, despite the lower heterogeneity observed in cell-line derived models. CDX models are established quicker, have relatively simple properties, and are cost-effective. For these reasons, CDX models may be preferred over PDX models for large scale drug efficacy screening.

CDX model studies also benefit from the wide range of available cancer types and subtypes. The diseased cells can be collected from various cell lines, providing a broad application landscape for evaluating drug response across multiple organ and tissue types.