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May 04,2023
A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation
In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields.
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A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp<sup>3</sup>-Sp<sup>2</sup> Bond Formation
Nov 19,2024
Medicilon Boston's Second R&D Center Grandly Sets Sail
On November 15th, Medicilon proudly unveiled its second R&D center in Boston, a milestone that reinforces its commitment to global drug innovation and its strategic expansion into international markets.
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Medicilon Boston's Second R&D Center Grandly Sets Sail
Aug 16,2024
XXVIII EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2024)
ACS Fall 2024——Elevating ChemistryConnect with peers. Get the latest insights in chemistry.Founded in 1876 and chartered by the U.S. Congress, ACS is one of the world's largest scientific organiza
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XXVIII EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2024)
Jul 12,2024
Join Medicilon at ACS Fall 2024
ACS Spring 2024——Many Flavors of ChemistryConnect with peers. Get the latest insights in chemistry.Founded in 1876 and chartered by the U.S. Congress, ACS is one of the world's largest scientific
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Join Medicilon at ACS Fall 2024
Jun 11,2024
RICT 2024 - 58th International Conference on Medicinal Chemistry
RICT 2024 - 58th International Conference on Medicinal ChemistryThis time, let's meet in France!RICT 2024 - 58th International Conference on Medicinal Chemistry is only three weeks to go! Med
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RICT 2024 - 58th International Conference on Medicinal Chemistry
May 19,2024
38th ACS National Medicinal Chemistry Symposium (NMCS Seattle 2024)
38th ACS National Medicinal Chemistry SymposiumFor four days, Seattle will be the setting of a high-profile and international scientific meeting. The scientific program will be composed of six session
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38th ACS National Medicinal Chemistry Symposium (NMCS Seattle 2024)
Mar 11,2024
The 19th Annual Drug Discovery Chemistry
19th Annual Drug Discovery ChemistryOptimizing Small Molecules for Tomorrow's TherapeuticsDrug Discovery Chemistry is a dynamic conference for medicinal and biophysical chemists working in pharma, bio
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The 19th Annual Drug Discovery Chemistry
Feb 04,2024
Join Medicilon at ACS Spring 2024
ACS Spring 2024——Many Flavors of Chemistry Connect with peers. Get the latest insights in chemistry. Founded in 1876 and chartered by the U.S. Congress, ACS are one of the world's largest scientific o
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Join Medicilon at ACS Spring 2024
Dec 18,2023
The 4th Alpine Winter Conference on Medicinal and Synthetic Chemistry
4th Alpine Winter Conference on Medicinal and Synthetic ChemistryThe "Alpine Winter Conference on Medicinal and Synthetic Chemistry” exposes attending scientists to cutting edge synthetic and medicina
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The 4th Alpine Winter Conference on Medicinal and Synthetic Chemistry
Oct 28,2023
​Join Medicilon at SITC 2023 in San Diego
We look forward to meeting you at EFMC-ISCB 2023!The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) and the Swiss Chemical Society, Division for Medicinal Chemistry & Che
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​Join Medicilon at SITC 2023 in San Diego
Oct 07,2023
Join Medicilon at ELRIG Drug Discovery 2023 - Diverse Thinking, New Perspectives
ELRIG Drug Discovery 2023 is only one week to go! Medicilon is excited to exhibit in the conference. This time, you can not only visit our table Stand H1, but also focus the speech "CHEMISTRY ENABLING
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Join Medicilon at ELRIG Drug Discovery 2023 - Diverse Thinking, New Perspectives
Aug 24,2023
Join Medicilon at the 13th DRUG DISCOVERY Strategic Summit
This time, let's meet in France!RICT 2023——57th International Conference on Medicinal Chemistry is only two weeks to go! Medicilon is excited to exhibit in the conference. Medicilon 
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Join Medicilon at the 13th DRUG DISCOVERY Strategic Summit
Jul 17,2023
One of the biggest challenges in drug discovery is to identify high-quality hit and lead compounds
Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organi
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One of the biggest challenges in drug discovery is to identify high-quality hit and lead compounds
Jul 17,2023
Based on structure–activity relationship analysis, compound with a simplified structure but excellent antifouling activities was synthesized
Biofouling poses one of the most serious problems to marine industry and aquaculture development. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces stra
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Based on structure–activity relationship analysis, compound with a simplified structure but excellent antifouling activities was synthesized
Jul 11,2023
A new LC-MS/MS method for the simultaneous quantification of Dabrafenib and its main metabolite hydroxy-dabrafenib (OHD) in human plasma has been developed and validated
Increased understanding of molecular pathways leads to the development of effective targeted therapies for the treatment of solid tumors. Dabrafenib (DAB) undergoes oxidative metabolism via cytochrome
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A new LC-MS/MS method for the simultaneous quantification of Dabrafenib and its main metabolite hydroxy-dabrafenib (OHD) in human plasma has been developed and validated
Jul 11,2023
GS-5801 is a potent KDM5 inhibitor with antiviral activity against HBV. GS-5801 was synthesized by Medicilon
Chronic Hepatitis B virus is one of the main causes of liver diseases including cirrhosis and hepatocellular carcinoma. Isonicotinic acid inhibitors of the histone lysine demethylase 5 (KDM5) with pot
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GS-5801 is a potent KDM5 inhibitor with antiviral activity against HBV. GS-5801 was synthesized by Medicilon
Jul 11,2023
zapERtrap: A light-regulated ER release system reveals unexpected neuronal trafficking pathways. Synthesis of zapalog was performed by Medicilon
zapERtrap opens the door to previously unapproachable questions concerning how proteins are processed, trafficked, and secreted in space and time in complex cellular environments. zapERtrap relies on
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zapERtrap: A light-regulated ER release system reveals unexpected neuronal trafficking pathways. Synthesis of zapalog was performed by Medicilon
Jun 23,2023
Join Medicilon at RICT 2023——57th International Conference on Medicinal Chemistry
This time, let's meet in Boston again! The 2023 BIO International Convention is a world-renowned event in the biotechnology industry, gathering leading biopharmaceutical companies, inves
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Join Medicilon at RICT 2023——57th International Conference on Medicinal Chemistry
May 08,2023
【Expert Report】Dr. Xingquan Ma: Medicinal Chemistry in Small Nucleic Acid Drug Discovery
On March 24, 2023, Dr. Xingquan Ma, SVP of the Chemistry Department of Medicilon, gave a report titled "Medicinal Chemistry in Small Nucleic Acid Drugs Discovery" during the IDC2023 4th Chemical New Drug and Improved New Drug R&D Forum. Medicilon can provide monomer synthesis and modification; oligonucleotide synthesis; delivery system synthesis and synthesis of oligonucleotide conjugates.
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【Expert Report】Dr. Xingquan Ma: Medicinal Chemistry in Small Nucleic Acid Drug Discovery
Apr 22,2023
Medicilon Platform Technologies to Enable Novel Drug Discovery
Medicilon's drug discovery service contains: Chemistry and Biology. Click to find Medicilon's Drug Discovery Service platform. We help you to accelerate your drug discovery process.
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Medicilon Platform Technologies to Enable Novel Drug Discovery