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Preclinical Research

Pharmacology & Pharmacodynamics

Tumor Models PDX Models Large Animal Models PDXO Models Digestive System Disease Models Endocrine & Metabolic Disease Models Inflammatory & Immune Diseases Models Neural System Disease Models Other Disease Models Ocular Diseases Models Cardiovascular Model
Drug Safety Evaluation

Pharmacology & Toxicology Study Safety Pharmacology Histopathological Study Clinicopathological Study Drug Safety Evaluation Basic Information Toxicokinetics
DMPK

In Vitro ADME Assays In Vivo Pharmacokinetic Assays
Bioanalysis

Macromolecular Drugs Bioanalysis Micromolecular Drugs Bioanalysis
IND Filings

FAQs

HomeservicesPreclinical ResearchPharmacology & PharmacodynamicsTumor ModelsGEM Models

GEM Models

Genetically engineered mouse (GEM) models are widely used and have proved to be a powerful tool to improve drug discovery processes. Using transgenic technology, extra DNA that encodes the gene of interest can be integrated into the mouse genome; using knockout or knock-in technology, specific regions of the mouse genome can be selectively deleted or modified.

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Genetically engineered mouse (GEM) models are widely used and have proved to be a powerful tool in drug discovery processes.
GEM models have become an invaluable tool for validating targets, identifying pharmacodynamic markers of drug action, detecting toxicity, and evaluating safety. Improvements in technologies and the development of new GEMs are expected to guide future applications of these models to drug discovery and preclinical trials.
Cell Line
PD-1CTLA-4PD-1 & CTLA-4

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Xenograft Models Orthotopic Cancer Models Syngeneic Mouse Models Humanized Mouse Models GEM Models PDX Model