Over 20 years of experience in R&D

01 Drug Discovery

Chemistry Research

Biology Research

Early Pharmacokinetics

02 Pharmaceutical Research

Intermediates

Active Pharmaceutical Ingredients

Pharmaceutical preparation

Analytical Method Development and Quality Control

CMC Filings

Analytical Testing Center

03 Preclinical Research

Pharmacology & Pharmacodynamics

Drug Safety Evaluation

DMPK

Bioanalysis

IND Filings

01 One-stop Integrated Services

Liposome Drug Development

Drug Discovery

Pharmaceutical Research

Preclinical Research

Botanical Drug Preclinical R&D

02 Innovative Drug Services

ADC

PROTAC

mRNA Vaccine

Cellular Immunotherapies

Nucleic Acid Drug

Peptide Drug Conjugate (PDC)

Antibody

03 Key Technical Services for Drug R&D

Cytokine and Biomarker Detection

Metabolite Identification (MetID)

Drug Forming Research

Flow Cytometry Technology

SEND Format Conversion

Flow Sorting

NanoString nCounter Detection

Routes of Drug Administration

04 Drug Efficacy Evaluation for Common Diseases

IO Pharmacodynamic Model

Inflammatory and Immune Diseases

Rodent Cerebrovascular Disease

05 Advanced Preparation R&D

Inhalation drug

Ophthalmic drug

Skin Topical Preparation

06 Targeted Drugs R&D Services

STAT3-targeted Drugs R&D Service

GLP-1 New Drug R&D Service

KRAS-targeted Drugs R&D Service

2024-07-22Medicilon Events

The Shanghai Overseas Returned Scholars Association invites the Dutch PhD delegation to visit Medicilon, exploring paths for innovative development together

On July 4th, the Shanghai Overseas Returned Scholars Association invited the Dutch PhD delegation to visit the Chuansha campus of Shanghai Medicilon Inc. (Medicilon) and held discussions with Medicilon's Founder and CEO, Chunlin Chen, among others.

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2024-07-22Medicilon Events

5th consecutive win! Medicilon once again made the list of "Top 20 Chinese R&D CRO Enterprises in 2024"

Medicilon stood out among hundreds of pharmaceutical enterprises and was honored with the "Top 20 Chinese R&D CRO Enterprises in 2024" award.

Medicilon 688202

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U.S.

Address: 20 Maguire Road, Suite 103, Lexington, MA 02421(America)

Tel: +1(626)986-9880

Address: Allia Future Business Centre Kings Hedges Road Cambridge CB4 2HY, UK

Tel: 0044 7790 816 954

Email: marketing@medicilon.com

China

Address: No.585 Chuanda Road, Pudong New Area, Shanghai (Headquarters)

Postcode: 201299

Tel: +86 (21) 5859-1500 (main line)

Fax: +86 (21) 5859-6369

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Preclinical Research

FAQs

HomeservicesPreclinical ResearchDrug Safety EvaluationToxicokinetics

Toxicokinetics

Medicilon has complete pharmacokinetic, toxicokinetic and analytical research facilities and instruments. Our Toxicology Research Department has been granted AAALAC Accreditation and GLP certificate from the NMPA and passed the on-site evaluation, with capabilities to support filing programs for multiple countries.

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Pharmacokinetic analysis can reveal the dynamic changes of drugs in vivo, the basic pharmacokinetic parameters of drugs, and clarify the process and characteristics of drug absorption, distribution, metabolism and excretion. It is an important starting point for animal species selection and understanding the relationship between dose-effect and toxicity-effect and can provide relevant information for designing and optimizing administration in clinical trials.

Toxicokinetics is an important part of pharmacotoxicology. It mainly studies the whole body exposure degree and duration of the tested substance at different dose levels to predict the potential risks of the tested substance when it is in the human body. Toxicokinetic tests are not a simple description of the basic pharmacokinetic parameters of drugs, they focus on explaining the results of toxicity test and predicting human safety.

Service

In vitro ADME research
Metabolic stability (liver microsomes, S9, Cytosol, hepatocytes and blood)Metabolite identificationDetermination of plasma protein binding rateCYP enzyme inhibition research (DDI and TDI)CYP enzyme induction researchTransporter substrate and inhibition evaluationEnzyme phenotype analysis
In vivo PK research
Selection of solvents and preparationsBridging experiment of preclinical preparation and clinical preparationBioavailabilityTissue distributionBile, urine and feces excretionBE researchPK/PD research Identification of metabolites in vivo
In vivo TK research
TK/PD/TOX analysisGender difference/dose correlation/accumulation analysisActive ingredient/prodrug/metabolite monitoringIdentification of metabolites of TK samplesImmunogenicity analysis
Biological sample analysis
Bioanalysis of preclinical samplesBioanalysis of clinical samplesanalysis of BE samples