Isotope-labeled Internal Standards Synthesis

Services include:

• 1. Synthesis services of standards and isotope internal standards
  Medicilon’s Chemical Synthesis and Radiosynthesis Laboratory offers rapid and short-term synthesis services for standards and isotope internal standards. These services encompass isotope labeling position selection, optimization of synthesis routes, purification and analysis of isotope products, and research and development of isotope-labeled biomacromolecules.
• 2. Pharmaceutical research and analysis services of radioisotope
  Medicilon provides pharmaceutical research and analysis services involving radioisotopes such as ³²P、³³P 、¹²⁵I、³⁵S、⁸⁹Zr and other radioactive isotopes for labeling experiments in the drug development process.
  Our services include:
  Distribution, metabolism and pharmacokinetics of drugs in vivoRadioreceptor assayRadioligand binding testRadioactive uptake testingCell growth testRadioimmunoassayImmunoradiation analysis, and more.
  Additionally, we hold a research license for radioisotopes(¹²⁵I, ¹⁴C, ³H) to study material balance and tissue distribution.
• 3. Synthesis of radiolabeled compounds
  Medicilon offers synthesis services for a variety of radiolabeled compounds, including aromatic compounds, heterocyclic compounds, polypeptides, oligonucleotides, conjugates, and polymers. This encompasses chiral compounds, antibody-drug conjugates (ADCs), and their respective linkers.We provide a wide range of analytical methods and develop specialized technologies, including GLP analysis. These methods include infrared spectroscopy, mass spectrometry, liquid chromatography (with radioactivity detection and polymer characterization capabilities), gas chromatography, NMR, differential scanning calorimetry, thermogravimetric analysis and ICP-MS, bioburden test and XRPD analysis.

Advantages:

• Extensive experience in chemical synthesis combined with efficient isotopic labeling chemistry. Access to laboratories compliant with GLP and GMP standards for completing radiolabeled chemical projects. Monitoring of isotope labeling chemistry progress to promptly supply customers with various isotope labeling intermediates.

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