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SERVICES

SERVICES

01 Drug Discovery

Chemistry Research Biology Research Early Pharmacokinetics

02 Pharmaceutical Research

Intermediates Active Pharmaceutical Ingredients Pharmaceutical preparation Analytical Method Development and Quality Control CMC Filings Analytical Testing Center

03 Preclinical Research

Pharmacology & Pharmacodynamics Drug Safety Evaluation DMPK Bioanalysis IND Filings

PLATFORM

PLATFORM

01 One-stop Integrated Services

Liposome Drug Development Drug Discovery Pharmaceutical Research Preclinical Research Botanical Drug Preclinical R&D

02 Innovative Drug R&D Services

Peptide Drug Conjugate (PDC) Antibody Nucleic Acid Drug Cellular Immunotherapies mRNA Vaccine PROTAC ADC

03 Key Technical Services for Drug R&D

Cytokine and Biomarker Detection Metabolite Identification (MetID) Drug Forming Research Flow Cytometry Technology SEND Format Conversion Flow Sorting NanoString nCounter Detection Routes of Drug Administration

04 Drug Efficacy Evaluation for Common Diseases

Rodent Cerebrovascular Disease Inflammatory and Immune Diseases IO Pharmacodynamic Model

05 High-end Preparations Technology Platform

Skin Topical Preparation Ophthalmic drug Inhalation drug

06 Targeted Drugs R&D Services

STAT3-targeted Drugs R&D Service KRAS-targeted Drugs R&D Service GLP-1 New Drug R&D Service

07 Safety Assessment Lab of Process Chemistry

08 Public Services

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CN

中

Syngeneic Mouse Models

Drug Discovery Pharmaceutical Research Preclinical Research

Preclinical Research

HomeservicesPreclinical ResearchPharmacology & PharmacodynamicsTumor ModelsSyngeneic Mouse Models

Syngeneic Mouse Models

Syngeneic mouse models test the ability of animals to fight cancer with an intact immune system and is used to test the therapeutic effects of immunotherapy. We can provide various syngeneic models to test the effectiveness of drugs according to our clients' requirements. Typical orthotopic disease models include breast cancer, lung cancer, colon cancer, kidney cancer and diffuse large B-cell lymphoma (DLBCL), utilising mice, rats and hamsters as test subjects.

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Model Type

Cancer Type	Cell Lines
AML	C1498,L1210, WEHI-3
Bladder cancer	MB49
Breast cancer	EMT6, JC,EO771(ATCC), 4T1,4T1-luc, C1271
Colon cancer	CT26.WT, CT26.WT-luc, MC-38, Colon26, CMT-93
DLBCL lymphoma	A20,P388D1, L5178-R (LY-R),E.G7-OVA
Hepatoma	H22
Kidney cancer	RENCA
Leukemia	C1498, L1210, WEHI-3
Liver cancer	H22, H22-Luc, Hepa 1-6
Lung cancer	LLC1, LLC1-luc, KLN205
Lymphoma	A20, EL4, L5178-R, E.G7-OVA
Mastocytoma	P815
Melanoma	B16-F10, Clone-M3
Myeloma	J558
Renal cancer	RENCA
Pancreatic cancer	Panc 02
Plasmacytoma	MPC-11

Relevant laboratories

Relevant articles

Xenograft Models Orthotopic Cancer Models Syngeneic Mouse Models Humanized Mouse Models GEM Models PDX Model

Global

Address: 20 Maguire Road, Suite 103, Lexington, MA 02421(America)

Tel: +1(781)535-1428(U.S.)

Address: Allia Future Business Centre Kings Hedges Road Cambridge CB4 2HY, UK

Tel: 0044 7790 816 954 (Europe)

Email: marketing@medicilon.com

Address: 5th Floor, 62, Banpodae-ro 4-gil, Seocho-gu, Seoul, 06719 South Korea

Tel: +82 70-8269-5849

China

Address: No.585 Chuanda Road, Pudong New Area, Shanghai (Headquarters)

Postcode: 201299

Tel: +86 (21) 5859-1500 (main line)

Fax: +86 (21) 5859-6369

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