Pharmacology & Pharmacodynamics

Keeping pace with industrial development and market demand, Medicilon's experienced Pharmacology and Pharmacodynamics Department has established a complete animal model library based on verification, precise and efficient drug efficacy testing. The test subjects we provide include non-human primates, dogs, rats, mice, rabbits, guinea pigs, and miniature pigs.

Support research on the efficacy of combined radiotherapy and chemotherapy treatmentsSupport research on the efficacy of combination of small and large molecule drugsSupport research on the efficacy of the evaluation of various non-oncology drugs

Tumor animal models
186 Xenograft Models30 Humanized Models30 Syngeneic Models50 Orthotopic Models100 PDX Models
Data as of 2024.03.27

Non-tumor animals models
64 CNS Diseases Models32 Inflammation & Immune System25 Cardiovascular Models18 Digestive System Disease Model10 Ocular Disease Model39 Endocrine & Metabolic Disease Models52 Other Disease Models
Data as of 2024.03.27

Feature Platform

Nucleic Acid Drug Pharmacology Evaluation In vivo Pharmacodynamic Studies of Cellular Immunotherapies In Vivo Efficacy Tests of PROTAC-POI Pharmacology Evaluation of ADC

Neural System Disease Models

Our Pharmacodynamics Department can deliver multiple nervous system models based on anti-depressants, anti-Alzheimer's drugs, sedative-hypnotic and anti-anxiety drugs, analgesics, anti-convulsants, anti-Parkinson's drugs, and anti-schizophrenia drugs. Those models can effectively evaluate innovative drugs at the molecular and cellular level, as well as ex vivo, and in vivo. The Department's advanced Cognition Wall Discrimination learning ensures uninterrupted tracking to determine changes in memory function in double transgenic mice during early-stage Alzheimer's disease and eliminates the disadvantages of the Morris water maze (MWM) in stress interference and short-time tests.

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Other Disease Models

Medicilon offers various effective animal models, including customized ones, based on clients' needs. Typical models include those for full-thickness skin trauma, pressure ulcers, and spontaneous hypertension with rats/mice and SHR as subjects. Further, Medicilon also offers non-human primates for pharmacology studies, such as using monkeys for cell therapy for Type-1 diabetes; and mini-pig for analgesic effect evaluation.

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Ocular Diseases Models

Medicilon has established ocular diseases models, including the Conjunctival tissue proliferation and NV, Diabetic retinopathy (DR), Choroidal neovascularization (CNV) and subretinal fibrosis, Corneal neovascularization (Corneal NV), Retinal neovascularization, Acute ocular inflammation, and dry eye models.

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Cardiovascular Model

Medicilon has established many cardiovascular models including the Dyslipidemia, Thrombosis & anemia, MCAO, and Anemia models for pharmacodynamics research.

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