PDX Model

The Patient-Derived Tumor Xenograft (PDX): model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy . Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.

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Model Type

Patient-Derived Tumor Xenograft (PDX) models retain the characteristics of patients’ tumor tissues and demonstrate more clinical relevance than CDX models. Combined with humanized mice, the model can promise optimum evaluation of tumor immuno-oncology therapeutics. We have the following models with more under development:

Cancer Type	Cell Lines
Colon cancer	PDXM-008C, PDXM-016C, PDXM-020C, PDXM-021C, PDXM-057C, PDXM-060C, PDXM-075C, PDXM-076C, PDXM-087C, PDXM-104C, PDXM-095C, PDXM-084C, PDXM-072C, PDXM-069C, PDXM-057C, PDXM-015C, PDXM-002C,
Lung cancer	PDXM-054Lu, PDXM-050Lu, PDXM-047Lu, PDXM-053Lu, PDXM-028Lu,
Gastric cancer	PDXM-092Ga, PDXM-091Ga,
Breast cancer	PDXM-201B, PDXM-202B, PDX-203B
Liver cancer	PDXM-211Li, PDXM-212Li
Pancreas cancer	PDXM-221Pa, PDXM-222Pa
Bladder Cancer	PDXM-231U, PDXM-232U
Lymphoma	PDXM-241Ly, PDXM-242Ly

PDX Models
SNI:Neuro-Oncology 2015, Vol 6, Suppl I - A supplement to Surgical Neurology International

Our research on PDX model includes molecular level genotyping and pharmacological efficacy evaluation service of orthotopic model, promising great prediction for clinical efficacy research.

PDX Model (Growth Curve)

PDX Model (MED-PDX-001C H&E (10X))

FAQ

What is a PDX Mouse Model?

The PDX model, also as known as the patient-derived tumor xenograft (PDX) model, is constructed by directly transplanting tumor tissue from a patient into a severely immunodeficient mouse and allowing the tumor tissue to grow within the mouse.
Advantages of the PDX Model

No in vitro culture process is required to "screen" tumors
Maintains the original characteristics and heterogeneity of the tumors
Maintains the original characteristics and heterogeneity of the tumors
Preserves the original non-tumor stroma and microenvironment
Enables research on tumors derived from patients under various conditions.
Application of PDX Models

• New drug development
In particular, patient screening and predictive biomarker studies in clinical trials of tumor immune-targeted drugs show that PDX efficacy evaluation results and clinical similarity reached 87% (CDX only 5%).
• Personalized Medicine:
PDX model can be used to conduct pharmacodynamic (PD) evaluation experiments for tumor patients, providing clinical drug references for personalized treatment.
• Molecular Marker development (Biomarker)
Drug reactions -- Molecular biological mechanisms

Relevant laboratories

Relevant articles

Xenograft Models Orthotopic Cancer Models Syngeneic Mouse Models Humanized Mouse Models GEM Models PDX Model