PDX Models

The Patient-Derived Tumor Xenograft (PDX): model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy . Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.

Download

As a one-stop preclinical research and development service platform in biopharmaceutical, Medicilon has continually innovated and refined its approach over the past 20 years. Medicilon has established a comprehensive and advanced efficacy evaluation system in the field of tumor drug development, encompassing over 410 tumor efficacy evaluation models, including 118 PDX (Patient-Derived Tumor Xenograft) orthotopic models.

Medicilon PDX Model Types

Medicilon’s 118 PDX orthotopic models cover a wide range of tumor types, from common to rare, providing diverse options for tumor biology research and drug screening. The specific models are as follows:

Cancer Type	PDX Model Number
Brain Cancer	551Br
Breast Cancer	201B, 203B
Cervical Cancer	371Ce
Colon Cancer	002C, 008C, 011C, 013C, 015C, 016C, 020C, 021C, 057C, 058C, 059C, 060C, 061C, 062C, 064C, 065C, 069C, 070C, 072C, 075C, 076C, 084C, 087C, 088C, 095C, 102C, 104C, 110C, 116C, 117C, 128C, 143C, 163C
Endometrial Cancer	361En
Esophageal Cancer	165Es, 166Es, 341Es
Gastric Cancer	091Ga, 092Ga, 122Ga, 126Ga, 142Ga, 145Ga, 254Ga, 256Ga, 258Ga, 147Ga, 153Ga, 152Ga, 151Ga, 156Ga, 154Ga, 150Ga, 155Ga, 157Ga, 158Ga, 159Ga
Head and Neck Cancer	281T, 285HN, 284HN, 286HN
Liver Cancer	212Li, 213Li, 214Li, 216Li, 217Li
Lung Cancer	028Lu, 047Lu, 050Lu, 053Lu, 054Lu, 168Lu, 171Lu, 263Lu, 264Lu, 265Lu, 267Lu, 269Lu
Melanoma	571Me
Ovarian Cancer	271O, 272O, 273O, 274O
Pancreatic Cancer	167Pa, 221Pa, 222Pa, 223Pa, 224Pa, 225Pa, 226Pa, 228Pa
Prostate Cancer	351Pr, 353Pr, 354Pr, 355Pr, 226Pa, 228Pa
Kidney Cancer	301R, 303R, 304R
Sarcoma	332Sa, 333Sa, 334Sa
Bladder Cancer	232U, 234U, 235U, 236U, 237U
Leukemia	291Le, 292Le, 293Le, 294Le, 295Le
Lymphoma	244Ly, 245Ly
Myeloma	321MM

Application of Medicilon PDX Orthotopic Model
SNI:Neuro-Oncology 2015, Vol 6, Suppl I - A supplement to Surgical Neurology International
PDX Model (Growth Curve)
PDX Model (MED-PDX-001C H&E (10X))
Advanced Detection and Research Technology Assurance
Medicilon employs a range of advanced technologies, such as in vivo imaging and ultrasound, to ensure the accuracy and reliability of PDX models, including:
1. In Vivo Imaging Technologies:
(1) PET/CT Molecular Imaging: Primarily used for assessing tumor model establishment, screening tumor models, detecting tumors, and evaluating drug efficacy.
(2) Visible Light Imaging: Includes techniques such as fluorescence imaging and bioluminescence in vivo imaging, which enable non-invasive real-time monitoring of tumor growth.
2. Ultrasound Technology:
Utilizing principles of Doppler ultrasound and echo imaging, this technology can display localized substantial tumors. It is particularly suitable for monitoring orthotopic tumor models in areas such as the kidneys, pancreas, ovaries, and bladder.

Partial Display of Medicilon’s PDX Orthotopic Models:

1. Orthotopic Liver Cancer PDXM-212Li
Animal: Female Nude Mice
PDX：PDXM-212Li
Tissue Type: Liver
Model Establishment: Orthotopic implantation of tumor tissue blocks
Imaging: Ultrasound (L38-22, 30 MHz)
2. Orthotopic Pancreatic Cancer PDXM-222Pa
Animal: Female Nude Mice
PDX：PDXM-222Pa
Tissue Type: Pancreas
Model Establishment: Orthotopic implantation of tumor tissue blocks
Imaging: Ultrasound (L38-22, 30 MHz)
3. Orthotopic Ovarian Cancer PDXM-271O
Animal: Female Nude Mice
PDX：PDXM-271O
Tissue Type: Ovary
Model Establishment: Orthotopic implantation of tumor tissue blocks
Imaging: Ultrasound (L38-22, 30 MHz)
4. Orthotopic Bladder Cancer PDXM-237U
Animal: Female Nude Mice
PDX：PDXM-237U
Animal: Female Nude Mice
Model Establishment: Orthotopic implantation of tumor tissue blocks
Imaging: Ultrasound (L38-22, 30 MHz)
5. Orthotopic Kidney Cancer PDXM-303R
Animal: Female Nude Mice
PDX：PDXM-303R
Tissue Type: Kidney
Model Establishment: Orthotopic implantation of tumor tissue blocks
Imaging: Ultrasound (L38-22, 30 MHz)

FAQs

What is a PDX Mouse Model?

The PDX model, also as known as the patient-derived tumor xenograft (PDX) model, is constructed by directly transplanting tumor tissue from a patient into a severely immunodeficient mouse and allowing the tumor tissue to grow within the mouse.
Advantages of the PDX Model

No in vitro culture process is required to "screen" tumors
Maintains the original characteristics and heterogeneity of the tumors
Maintains the original characteristics and heterogeneity of the tumors
Preserves the original non-tumor stroma and microenvironment
Enables research on tumors derived from patients under various conditions.
Application of PDX Models

• New drug development
In particular, patient screening and predictive biomarker studies in clinical trials of tumor immune-targeted drugs show that PDX efficacy evaluation results and clinical similarity reached 87% (CDX only 5%).
• Personalized Medicine:
PDX model can be used to conduct pharmacodynamic (PD) evaluation experiments for tumor patients, providing clinical drug references for personalized treatment.
• Molecular Marker development (Biomarker)
Drug reactions -- Molecular biological mechanisms

Relevant laboratories