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Orthotopic Cancer Models

Orthotopic Cancer Models

The orthotopic cancer model assesses the interaction between tumor cells and drugs in their natural organ/microenvironment and monitors tumor growth in situ. We have a variety of mature orthotopic transplantation models available, including brain, liver, lung, tibial bone marrow cavity, and intravesical orthotopic transplantation models.
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Medicilon icon-diamond.pngModel Type
Cancer TypeCell Lines
Brain cancerU87-MG, G261, U251, U87-MG-luc, G261-luc, U251-luc
Breast cancerMDA-MB-231, MDA-MB-231-luc, 4T1, 4T1-luc, HCC1954, HCC70, MDA-MB-361, MCF7
Bladder cancerUM-UC-3, MB49
Colon cancerHCT-116, LoVo, HT29-luc, HT29, MC38, MC38-luc, CT26.WT-luc
GlioblastomaU87-MG, U87-MG-luc
Gastric cancerHs 746T
Kidney cancerA498
LeukemiaK562, K562-luc, MV-4-11, MV-4-11-luc, THP-1, Nalm-6, Nalm-6-luc, MOLM-13, MOLM-13-luc, RL, MAVER-1, Karpas299, HL-60
Liver cancerH22,  H22-luc, HuH-7, HuH-7-luc, Hep G2, Hep G2-luc
LymphomaRaji, Raji-luc
MelanomaB16-F10, B16-F10-luc
MyelomaNCI-H929, MM.1S, NCI-H929-luc, MM.1S-luc
OsteocarcinomaSJSA-1
Ovarian cancerSK-OV-3, SK-OV-3-luc
Pancreatic cancerMia-Paca 2, Mia-Paca 2-luc
Pancreas cancerMia-Paca 2, Mia-Paca 2-luc, Panc02, Panc02-luc
Prostate cancerPC3, PC-3-luc
Renal cancerA498
Lung cancerNCI-H460, NCI-H1650, NCI-H1975, NCI-H1975-luc, A549, A549-luc, LLC1, LLC1-luc
Medicilon icon-diamond.pngMature Orthotopic Technique
  • Orthotopic brain tumor models
    Orthotopic brain tumor models.png
  • Lung tumor models
    Lung tumor models.png
    Tibia marrow cavity tumor models
    Tibia marrow cavity tumor models.png
  • Ovary carcinoma models
    Ovary carcinoma models.png
Relevant laboratories
  • caliper
  • BD-FACSCelesta
  • BD-LSRFortessa
  • IVIS-Lumina-III-In-Vivo-Imaging-System
  • RAD
  • frozen section
  • Pathological observation
  • pathological section
  • Operating room (outer room)
  • flow cytometer
Relevant articles