Medicinal Chemistry

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Service

• Medicilon’s medicinal chemistry services include:
  Feasibility assessment of new drug targetsHigh-throughput screening and discovery of active compounds based on  structural designSAR-based compound synthesis and optimizationEstablishment of specific compound libraries (micro-molecule compound library)Rapid synthesis of PROTAC molecules and ADC payloads, as well as lipids, glycolipids, and phospholipidsScreening of new hit compounds (from active compounds to discovery of lead compounds) Synthesis, discovery, and optimization of hit compoundsResearch on SARComputer-aided drug design (CADD) Processes from lead compound optimization to determination of preclinical drug candidatesPatent preparation and applicationELN system recordsMulti-parameter lead optimization for desired target molecule profiles (synthesis, discovery, and structural optimization of lead compounds)

Features

• An efficient team is driven by strict deadlines:
  The chemistry department of Medicilon has 1500 employees:Over 40% of our team members hold a master's degree, doctorate, or above.We maximize every second to ensure overall efficiency and project punctuality.Average working experience ofjunior research staff (researchers) : 3-5 yearsmiddle-level researchers (group leader level): 8-10 yearssenior level (director level and above): 15-20 years            Efficient team performance parameters: Fee for service (FFS) on-time delivery rate > 80%; Chemical reaction success rate > 85%;One compound delivered per full-time equivalent (FTE) each week;Number of reactions completed by each scientific researcher each week > 12.
• Advanced equipment
  Supported by high-throughput chromatography and mass spectrometry and advanced processing software, Medicilon sets high standards for our compound screening and analysis, optimization of lead compounds, analysis of chemical and physical properties of compounds, and other drug R&D processes. Our 10,000 m² laboratory in Shanghai Nanhui Industrial Park is equipped with a comprehensive library of instruments and is managed via a modern business model. We  guarantee the quality and efficiency of every project we undertake.
• Featured Platform-PROTACs Drug
  Our Medicinal Chemistry Department has established a PROTAC drug discovery platform that includes popular target protein ligands. We have also developed libraries for high-affinity targeting protein small molecules (TPSM) and small molecular fragments, as well as libraries for high-affinity ubiquitin ligase small molecule (E3SM) and small molecular fragments. Additionally, we have diversified bi-functional linker systems (BF-Linker).Those compound libraries facilitate the rapid and efficient synthesis of numerous high-activity PROTAC bi-specific small molecules, significantly accelerating the process of drug R&D. Medicilon will make every effort to establish and complete its PROTAC biological screening and testing platform, as well as the subsequent development stages of preclinical research.
• Featured Platform - Nucleic Acid Drugs
  Medicilon's nucleic acid drug discovery platform is an integrated and comprehensive platform for drug discovery, manufacturing and preclinical research. Medicilon has built an siRNA library with not only a rich inventory of monomers, but also a large library of monomer synthesis blocks, which can rapidly complete the synthesis of various types of modified monomers. Medicilon has a professional small nucleic acid drug development team, and several siRNA drug FTE projects have been completed and are in progress.
• Featured Platform-ADC Drugs
  Each ADC R&D project provides its own challenges due to the varieties in the assembly of ADC molecules. With this in mind, Medicilon promises careful planning, meticulous execution and accurate results achievable because we have many years of practical experience and undertake effective communication with our clients.

Service Cases

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