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| Disease | Type | Species |
|---|---|---|
| Arthritis | Acute joint inflammation (Carrageenan induction) | Rat |
| Acute joint inflammation induced CFA | Mouse/Rat | |
| Rheumatoid arthritis induced by II Collagen (CIA model) | Mouse/Rat | |
| Rheumatoid arthritis induced by Complete Freund’s Adjuvant (AIA model) | Rat | |
| Gouty arthritis model induced by sodium urate | Rat | |
| Osteoarthritis | Sodium iodoacetate (MIA) induced osteoarthritis | Rat |
| Partial Medial Meniscectomy (pMMx) induced osteoarthritis | Rat | |
| Partial Medial Meniscectomy with Anterior Cruciate Ligament severed (pMMx + ACLT) osteoarthritis | Rat | |
| Osteoporosis | Osteoporosis model of castrated female rat | Rat |
| Osteoporosis model (Retinoic acid A induction) | Rat | |
| Osteoporosis model (Glucocorticoid induction) | Rat | |
| Psoriasis | Vaginal epithelium mitosis (Estrogen induction) | Mouse |
| Tail scale model | Mouse | |
| Auricle epidermal dysplasia (IL-23 induction) | Mouse | |
| Back skin psoriasis (Imiquimod induction) | Mouse/Rat | |
| Atopic dermatitis and eczema | Atopic dermatitis model (MC903 induction) | Mouse |
| Atopic dermatitis model (Oxazolone induction) | Mouse | |
| Chronic atopic dermatitis model (DNFB induction) | Mouse/Rat | |
| Chronic atopic dermatitis model (DNCB+OX induction) | Mouse | |
| Subacute eczema-like model induced by DNFB | Mouse | |
| Eczema-like model induced by Phorbol ester | Mouse | |
| Multiple sclerosis , Amyotrophic lateral sclerosis (MS，ALS） | EAE allergic encephalomyelitis model (EAE) | Mouse |
| Cuprizone-induced demyelination of brain tissue | Mouse | |
| Pulmonary inflammation and fibrosis | Pulmonary inflammation model (LPS induction) | Mouse/Rat |
| Systemic inflammation model (LPS induction) | Mouse/Rat | |
| Pulmonary fibrosis model (Bleomycin induction) | Mouse/Rat | |
| Pulmonary fibrosis model (Paraquat induction) | Rat | |
| Silicosis model (Silicon dioxide induction) | Mouse/Rat | |
| Asthma | Bronchial asthma model (OVA + Aluminum hydroxide induction) | Rat |
| Nephritis | Heymann nephritis model | Rat |
| IgA nephritis model | Mouse | |
| Serum sickness nephritis model | Rat | |
| Alopecia and Alopecia areata | Alopecia (Rosin and Paraffin + Testosterone propionate induction) | Mouse |
| Alopecia (Testosterone propionate induction) | Mouse/Rat | |
| Alopecia (Dihydrotestosterone induction) | Mouse | |
| Alopecia areata (Imiquimod induction) | Mouse | |
| Alopecia areata (Cyclophosphamide induction) | Mouse | |
| Allergic rhinitis | Allergic rhinitis model (OVA + Aluminum hydroxide induction) | Mouse |
| Allergic rhinitis model (OVA + DPT vaccine induction without cell) | Rat | |
| Pruritus model | Pruritus model (Chloroquine induction) | Mouse |
| Acute pruritus model (Histamine induction) | Mouse | |
| Pruritus model (Histamine + 4-AP induction) | Mouse | |
| Pruritus model (Dextran induction) | Mouse | |
| Acute pruritus model (Compound 48/80 induction) | Mouse | |
| Pruritus model (MC903 induction) | Mouse | |
| Dry skin pruritus model | Mouse | |
| Humoral and cellular immune function | Immunodeficiency model (Dexamethasone induction) | Mouse |
| Heteroprotein-induced immune dysfunction model | Mouse | |
| Cellular immune function test in vivo | Mouse | |
| Humoral immune function test in vivo | Mouse | |
| Avaluating effects on mononuclear macrophage function in vivo | Mouse | |
| Inflammation and Swelling | Auricle swelling model | Mouse |
| Toe swelling model | Rat | |
| Capillary permeability test | Mouse/Rat | |
| Granuloma proliferation model | Rat | |
| Carbon Clearance Test | Mouse | |
| Fever model (Yeast induction) | Mouse | |
| Passive cutaneous anaphylaxis (PCA) | Mouse/Rat | |
| Immune-mediated inflammatory eye diseases | Allergic conjunctivitis (AC) model | Rat |
| Dry eye model | Rat |
Inflammatory and Immune Diseases Platform
The preclinical pharmacology department of Medicilon has been active in this field for many years, and has provided a variety of stable and reliable animal models for different targets and pathways for the evaluation of inflammatory immune disease treatments in order to support successful clinical translation.
FAQAutoimmune diseases are a group of disorders characterized by the body's immune response mistakenly causing autologous tissue damage in response to self-antigens. Common examples include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), psoriasis, and atopic dermatitis.
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