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Enzyme Catalysis

Enzyme Catalysis

As a CRO advocating for green drug research and development, Medicilon has consistently aimed to advance the environmental sustainability of pharmaceutical processes through technological innovation. Medicilon has already utilized enzymes in process research and development. Relying on its strong chemical and biological background, Medicilon has established the Enzyme Catalysis Technology Platform to screen catalytic enzymes for specific reaction types and establish corresponding enzyme libraries to support process development and production.

Medicilon Enzyme Catalysis Service Platform

  • 01 Chemical Technology Platform

    Development of Pharmaceutical Intermediates and APls

    Functional Chemical Development

    02 Biotechnology Platform

    Enzyme Development and Applications

    Enzyme Production

    03 Quality Technology Platform

    Quality and Control Research

    Inspection and Testing Services

    Medicilon Enzyme Catalysis Service Platform.jpg
    Medicilon's Enzyme Catalysis Technology Platform integrates a chemical technology platform, biotechnology platform, and quality technology platform. The platform emphasizes combining chemical synthesis with biological enzyme catalytic synthesis, conducting research on the development and application of biological enzymes, and engaging in R&D and production of pharmaceutical intermediates and APIs using green biotechnology. Additionally, it provides high-end CRO and CDMO services, along with testing and quality research services to pharmaceutical companies.

Medicilon Enzyme Library

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KetoreductaseD-amino acid dehydrogenaseTransaminaseNitrile HydratasePhenylalanine LyaseHydroaminase
Cytochrome MonooxygenaseThreonine DehydrogenasePhosphokinaseEpoxide HydrolaseNitrilase
Alcohol OxidaseFormate DehydrogenaseNucleoside Phosphorylation (synthesis)AmidohydrolaseAldol Condensase
Monoamine OxidaseGlucose DehydrogenaseNitrilaseOther Specialized Enzymes
NitrileLactateLactate
ReductaseDehydrogenaseDehydrogenase
NitroreductasePhenylalanine Dehydrogenase
Imine ReductaseAmmonia Dehydrogenase
  • Currently, Medicilon has successfully established dozens of major biological enzyme libraries, including ketoreductase, ester hydrolase, imine reductase, nitroreductase, cyclooxygenase, and amide hydrolase. These libraries provide suitable biocatalytic solutions for various chemical transformations. These integrated enzymatic services reduce costs, shorten timeframes, and improve quality. With the implementation of numerous projects, Medicilon's enzyme library continues to be optimized and expanded. Additionally, Medicilon will conduct research on immobilized enzymes and coenzymes.

Medicilon’s R&D capabilities in the field of synthetic biology

  • With the continuous advancement of synthetic biology technology, an increasing number of enzymes with specific catalytic functions are being used as biocatalysts to achieve reactions that are challenging with chemical catalysts. These enzymes also serve as catalytic components to construct functional modules in synthetic biology. Medicilon has already established a strong presence in this field. Through the assembly of different enzyme components, Medicilon has achieved breakthroughs in designing synthetic routes for numerous target molecules. We offer a variety of services including:
    Molecule and Strain ConstructionStrain Delection and DomesticationEnzyme Co-ExpressionMulti-Enzyme CatalysisBiocatalysisProtein ModificationFermentation MetabolismProtein PurificationFermentation OptimizationEnzyme Immobilization
    In the future, Medicilon, as a one-stop biopharmaceutical preclinical R&D service platform, will continue to explore and apply more innovative green chemical technologies. Our aim is to achieve more environmentally friendly, safe, efficient, and economical process development and production, creating innovative products for clients around the globe.
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