Cardiovascular Model

Medicilon has established many cardiovascular models including the Dyslipidemia, Thrombosis & anemia, MCAO, and Anemia models for pharmacodynamics research.

Disease	Type	Species
Dyslipidemia	Hyperlipidemia model (HFD/Cholesterol /Fructose diet induction)	Rat/ Hamster
Dyslipidemia	Hereditary atherosclerosis+HFD	APOE Mouse
Thrombosis, Anticoagulation, Hemophilia	Arteriovenous bypass thrombosis model	Mouse/ Rat
	Caudal vein thrombosis (Carrageenan induction)	Mouse
	Rat model of deep vein thrombosis	Rat
	Carotid artery thrombosis model	Mouse/Rat
	Bleeding time (BT) test	Mouse
	Coagulation time (CT) test	Mouse
	Four tests for coagulation (PT, APTT, TT, FIB)	Mouse/Rat
	F8-KO hemophilia model	Mouse
Middle Cerebral Artery Occlusion(MCAO)	Cerebral ischemia reperfusion: dose-dependent and time-effect relationship research	Mouse/Rat
	Time window for treatment of cerebral ischemia reperfusion injury	Mouse/Rat
	The neuroprotective effect of cerebral ischemia reperfusion	Mouse/Rat
	Permanent cerebral infarction model	Rat
Myocardial ischemia-reperfusion	Myocardial ischemia-reperfusion model	Rat
Anemia	Hypoferric anemia	Rat
	Renal anemia induced by 5/6 Nephrectomy	Rat
	Renal anemia induced by adenine	Rat

Cardiovascular and cerebrovascular diseases generally refer to ischemic or hemorrhagic diseases of the heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, and hypertension. Medicilon has established rat and mouse MCAO model evaluation system with stable lesions, high success rate, high survival rate and reliable and effective evaluation of dose-effect/time-effect relationship. We can provide efficacy evaluation of transient cerebral ischemia and permanent cerebral ischemia and complete the investigation of various pharmacodynamic core indicators according to STAIR technical guidelines. The model rodents could be customized with special diseases and complete activity evaluations according to customer requirements.

Disease Name	ICD 10	Model
Intracerebral hemorrhage	I60-I62	Intracranial autologous blood injection, subarachnoid hemorrhage
Cerebral infarction	I63	Ischemic stroke model
Stroke	I64
Cerebral Embolism	I65
Cerebral Embolism	I66
Other	I67-I69	Other

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