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Biology Research

Biology Research

Medicilon’s Biology Department boasts a variety of technical solutions, professional scientific research teams, various advanced biological instruments and biological laboratories. Medicilon has rich experience in biological fields such as molecular biology, cell biology, in vitro biology, structural biology, among others.

With our technical platforms such as enzyme-level and cell-level measurement platforms, we assist clients in compound selection and research into their properties, action mechanism and biomarker analysis, ensuring effective implementation of clients' projects and promoting drug R&D processes.

Biology Service Model & Advantages
  • biology.wenp
    biology.wenp
    Biology Division has dedicated over 19 years to drug discovery services Serving over 300 clients annuallyOver 1000 screening methods established, generating over 2 million data points per yearConducted conformational studies for more than 200 targetsCell library with over 400 tumor cell lines for drug sensitivity testingRich knowledge base with more than 50 new experimental methods and 5 new platforms annually.Clinical biomarker detection system progressively improved, capable of detecting biomarkers in human blood and tissue samples, with preparations underway for the NanoString nCounter tissue mRNA detection platform.
Feature Platforms
  • Kinase Screening PlatformEnzymatic/Molecular Interaction Screening PlatformCell Screening PlatformSmall Nucleic Acid Platform
Antibody Development Technology Service
Medicilon's antibody development technical service covers the full spectrum of Anti-Drug antibody development technical services and druggable antibody development technical services. We can provide ADA rabbit polyclonal antibody development, ADA mouse hybridoma monoclonal antibody development, phage display rabbit monoclonal antibody development services, mouse monoclonal antibody development technical services, and mouse/rabbit single B cell antibody development technical services, etc.
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Computational Biology & Molecular Modeling
In addition to traditional biological research methods, Medicilon has developed faster and more effective tools. By using computers and big data to assist in early drug R&D, we aim to reduce the workload of drug researchers, lower the cost of drug development and shorten cycles of drug development.
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CHO Cell Protein Expression System
Featuring protein folding and post-translational modification, mammalian protein expression systems can produce proteins that closely resemble natural proteins, ensuring identical biological activity and characteristics. Therefore, mammalian cell expression systems are extensively utilized in the R&D and production of recombinant protein drugs, particularly therapeutic recombinant monoclonal antibody drugs.
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Insect Cell Protein Expression System
The baculovirus expression vector system (BEVS) has been widely used since 1983 for preparing various recombinant proteins, particularly recombinant kinases and protein complexes. Our researchers have developed a mature baculovirus-insect cell expression service that includes preparing recombinant baculoviruses, and expressing and purifying recombinant proteins and their complexes.
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Yeast Protein Expression System
Widely used in the production and preparation of recombinant proteins, especially eukaryotic proteins, the yeast expression system combines the advantages of both prokaryotic and advanced eukaryotic systems. It is characterized by common culture conditions, fast growth, low cost, capability of post-translational processing of proteins, and easy access to soluble active recombinant proteins. Pichia pastoris has become the preferred yeast for expressing recombinant proteins due to its rapid growth, abundant commercial expression vectors, and highly efficient secretory expression.
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