Biology Research

Medicilon’s Structural Biology Laboratory is equipped with a molecular cloning room and offers a drug discovery and selection solution based on protein crystallography, supporting drug development from the determination of new targets to final structural determination.Our structural biology solution is one of the earliest established structural biology laboratories in China, and has been recognized as providing an important new drug R&D solution by the Shanghai Municipal People's Government..youtube-player { position: relative; padding-bottom: 56.23%; /* Use 75% for 4:3 videos */ height: 0; max-width: 100%; background-image: url(/d/image/20221014/63491583ed718.webp); background-size:cover; margin-top: 25px; } .youtube-player iframe { position: absolute; width: 100%; height: 100%; z-index: 100; background: transparent; }

Medicilon offers Cell Assay Analysis and Radioisotope Analysis for clients.

Medicilon has strong capability in assay development and compound screening.Our screening capacity could be 200x384 well/week,or customize it per clients' needs.We work closely with partners such as Selleck,MCE and Tocris that provide compound libraries, and we have more than a library of 3000 compounds in-house.

Medicilon's Biology Department has rich experience in the field of in vitro biology, offering a comprehensive range of biological services including enzyme-level measurements, cell-level measurements, cell biology, biochemistry, in vitro isotope measurements, establishment of stable cell lines, gene knockout, RNAi, and MicroRNA technology.

Antibody discovery technology plays a vital role in drug development, mainly discovering antibodies with specific binding activity by screening antibody libraries or antibodies obtained from animal immunization. This can help researchers accelerate the drug development process. It can also help researchers better understand diseases, including disease pathogenesis and discovering new therapeutic targets.

The Medicilon translational medicine platform has an experienced professional technical team. Starting from the mechanism of action of drug targets and the clinical application of biomarkers, the team combines a variety of different technology platforms and instruments to reduce the cost and time of drug R&D, and provide diverse and efficient services for different types of drugs, different kinds of pharmaceutical companies and projects at different R&D stages.

Medicilon has established an in vitro activity assay platform with more than 400 cell models and more than 200 in vitro enzyme assay methods. Medicilon provides cell activity assay services, SPR assay services and in vitro enzyme activity assay services.

As a CRO advocating for green drug research and development, Medicilon has consistently aimed to advance the environmental sustainability of pharmaceutical processes through technological innovation. Medicilon has already utilized enzymes in process research and development. Relying on its strong chemical and biological background, Medicilon has established the Enzyme Catalysis Technology Platform to screen catalytic enzymes for specific reaction types and establish corresponding enzyme libraries to support process development and production.

For cancer drug efficacy evaluation, Medicilon has developed 3D cell culture models with KRAS cell lines and associated diseases. Utilizing Medicilon's Ready-to-Use KRAS 3D Spheroid Models can enhance your preclinical research.

In vitro biological activity detection is a mandatory item for clinical application of biological products, with high requirements for method development, personnel operation stability, and laboratory compliance management. Medicilon's cell viability assay platform can provide compliant in vitro cell viability detection services that meet the application requirements. Our high-level scientific research team can assist customers in participating in new drug development and exploring drug action mechanisms, while our high-throughput screening platform can help customers conduct efficient drug screening.

Biacore 8K can detect almost all biomolecules from various organic small molecules, peptides, proteins, nucleic acids, carbohydrates, lipids, phages, viruses and cells. Biacore 8K can also be used to study the interaction network composed of different molecules, complex assembly, protein conformational changes, thermodynamic parameters of molecular binding, and post-translational modifications of proteins. Biacore 8K provides high-quality analytical data, thereby effectively solving related problems in the current life science field.

Kinases play extensive and important roles in signal transduction and co-ordination of complex functions. Currently, about 300 kinase inhibitors have been approved for marketing, among which receptor tyrosine kinase (RTK) inhibitors are the main ones. Medicilon provides high-quality kinase profile screening and has one-stop kinase research services from assay development, high-throughput screening to selectivity analysis. In addition, Medicilon provides many other enzyme activity screens.