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Ulotaront is a TAAR1 agonist with 5-HT1A agonist activity for the treatment of Schizophrenia.The distribution of Ulotaront to rat brain and monkey plasma PK was conducted at Medicilon

2023-07-17
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Ulotaront (SEP-363856) is a TAAR1 agonist with 5-HT1A agonist activity currently in clinical development for the treatment of Schizophrenia. Ulotaront exhibits rapid absorption, greater than 70% bioavailability, and good penetration across the blood–brain barrier in preclinical species. The distribution of Ulotaront to rat brain was conducted at Medicilon/MPI Preclinical Research. Ulotaront monkey plasma PK was conducted at Medicilon/MPI Preclinical Research. 

29.jpgReference:

Guangqing Xiao, et al. In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia. Pharm Res. 2022 May;39(5):837-850. doi: 10.1007/s11095-022-03267-1. 


Schizophreniarapid-absorptionbioavailabilitygood-penetrationblood–brain-barriermonkey-plasma-PK
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