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Amorphous solid dispersion of Sorafenib was used to develop an immediate release tablet with improved oral bioavailability. The PK study was performed by Medicilon

2023-07-11

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An amorphous solid dispersion (ASD) of Sorafenib (SOR) was used to develop an immediate release tablet with improved oral bioavailability. The SOR ASD tablets exhibited approximately 50% higher relative bioavailability in dogs than the marketed SOR tablet product, Nexavar®. The pharmacokinetic (PK) study of SOR ASD tablets and Nexavar® tablets was performed by Medicilon.

Reference:

Sichen Song, et al. Efficient development of sorafenib tablets with improved oral bioavailability enabled by coprecipitated amorphous solid dispersion. Int J Pharm. 2021 Dec 15;610:121216. doi: 10.1016/j.ijpharm.2021.121216.

Sorafenib oral-bioavailability pharmacokinetic PK

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