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Tel: +86 (21) 5859-1500
Apoptosis is a cellular process critical to the normal development and homeostasis of multicellular organisms.
The inhibitor of apoptosis proteins (IAPs) are a class of key apoptosis regulators. IAP proteins are attractive cancer therapeutic targets. SM-406 (compound 2) is a potent and orally bioavailable antagonist of the IAPs.
Pharmacokinetic (PK) studies of SM-406 (compound 2) in male Sprague Dawley rats, beagle dogs and cynomolgus monkeys (non-human primates) were performed by the Division of Pharmacokinetics and Metabolism, Medicilon.
SM-406 (compound 2) has an excellent PK profile and good oral bioavailability in each of these four species.
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