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The search for selective kappa opioid receptor (κOR) agonists with an improved safety profile is an area of interest in opioid research. SLL-1206 is a κOR agonist with single-digit nanomolar activities. SLL-1206 exhibits substantially improved physicochemical and pharmacokinetic properties, and reduces central nervous system effects.
The authors are grateful to Medicilon Preclinical Research LLC. for pharmacokinetic studies on SLL-1206.
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