PARP1/2 inhibitors are the promising candidate for the treatment of cancer. The PARP1/2 inhibition assays were performed by Medicilon

2023-07-11

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Poly ADP-ribose polymerases (PARPs) are a family of enzymes related to DNA damage repair process.

Inhibition of PARP1/2 accelerates the damage of injured DNA, which is synthetically lethal to DNA-repairing-deficient cancer cells, such as BRCA1/2-deficient cells.

PARP1/2 inhibitors could be a promising candidate for the treatment of cancer.

The PARP1 and PARP2 inhibition assays were performed by Medicilon.

Reference:

Lin Tang, et al. Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer. Bioorg Chem. 2021 Sep;114:105026. doi: 10.1016/j.bioorg.2021.105026.

PARP DNA-damage-repair inhibition-assay

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