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Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent. The binding inhibition activities of MT-1207 were evaluated by Medicilon

2023-07-11

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Hypertension is a serious public health problem worldwide. MT-1207 is a chemical entity that has entered into clinical trial as antihypertensive agent. MT-1207 potently inhibits adrenergic α1A, α1B, α1D, and 5-HT2A receptors with K_i<1 nM in a panel of enzyme activity or radioligand binding assays. The binding inhibition activities of MT-1207 were evaluated by Medicilon.

Reference:

Tian-Ying Xu, et al. Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent. Acta Pharmacol Sin. 2021 Jun;42(6):885-897. doi: 10.1038/s41401-021-00636-1.

Hypertension antihypertensive adrenergic-receptor

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