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H11-HLE is a tool molecule that allows the interrogation of the contribution of Fc in mediating immune checkpoint therapy with potent anti-tumor efficacy

2023-07-11
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4.jpgImmune checkpoint inhibition therapies have been used for multiple cancer research. H11-HLE is a tool molecule that allows the interrogation of the contribution of Fc in mediating immune checkpoint therapy. Half-life extended H11 (H11-HLE) induces potent anti-tumor efficacy in mouse syngeneic tumor models. 

Authors gratefully acknowledge performing in vivo studies by Medicilon Preclinical Research LLC who performed the in vivo experiments.

Reference:

Yosuke Sato, et al. Fc-independent functions of anti-CTLA-4 antibodies contribute to anti-tumor efficacy. Cancer Immunol Immunother. 2022 Oct;71(10):2421-2431. doi: 10.1007/s00262-022-03170-z. 


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