General principles of pharmacodynamic research: random, controlled, repeated
The basic methods of pharmacodynamic research: in vivo test and in vitro test, in which the new drug pharmacodynamic test has been mainly in vivo test, supplemented by in vitro test.
Dosing methods for pharmacodynamic studies: prophylactic, therapeutic, and combined prevention and administration
Medicilon’s Drug Safety Evaluation Service
Choose more than one animal for pharmacodynamic test, and use 2-3 animal models or cell models for each pharmacological effect.
The basic role of drugs
1. Side effects: other reactions produced by the drug at therapeutic doses that are not related to the purpose of treatment.
2. Toxic reaction: A harmful pathological reaction that occurs when the dose of the drug is too large, the drug is taken for too long, or the drug accumulates in the body too much.
3. After-effects: the remaining biological reactions after drug withdrawal
4. Drug withdrawal reaction: the disease worsens after drug withdrawal
5. Allergies: also known as allergic reactions
6. Specific reaction:
Drug dose and effect relationship
Dose-effect relationship: The pharmacological effect varies in proportion to the dose within a certain range
Dose response curve
1. Good response relationship: the effect changes in a proportional proportion within a certain range with the change of dose
Keeping pace with industrial development and market demand, Medicilon's experienced Pharmacology and Pharmacodynamics Department has established a complete animal model library based on verification, precise and efficient drug efficacy testing. The test subjects we provide include non-human primates, dogs, rats, mice, rabbits, guinea pigs, and miniature pigs.
2. Qualitative response
There are four kinds of pharmacological effects: total, none, positive and negative
The main content of the drug action mechanism:
1. Physical and chemical reaction (acid resistance)
2. Participate in or interfere with cellular metabolism
3. Affect the transport of physiological substances (diuretics)
4. Effect on enzymes
5. Ion channels acting on cell membranes
6. Affect accounting metabolism
7. Affect the immune mechanism
8. Non-specific effects (general anesthetic)
9. Receptor mechanism
Pharmacodynamic test content: in vitro pharmacodynamic test, in vivo pharmacodynamic test, mechanism study
Principles of pharmacodynamic testing: first in vivo, then in vitro; first important, then secondary; test plan basis, condition brief; test results, analysis, evaluation
Commonly used experimental animals:
Mice, rats, guinea pigs, hamsters
Rabbits, dogs, monkeys, cats, miniature pigs, chickens, etc.
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Email: marketing@medicilon.com
Phone: 8602158591500
Website: www.medicilon.com
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