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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Mar 12,2018
Alzheimer's Amyloid Gets Immune System Trim
Immune cells in the brain have a trigger, and when it is pulled, it prompts immune cells to degrade toxic β-amyloid (Aβ) proteins. This new finding, from Sanford Burnham Prebys Medical Research Institute (SBP), helps explain why a faulty trigger appears to raise the risk of Alzheimer's disease. Increasing the genetic expression of the triggerRead more
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Alzheimer's Amyloid Gets Immune System Trim
Mar 09,2018
Glucostat Discovery Has Implications for Diabetes Regenerative Therapies
Researchers in Sweden and the U.S. report new insights into how the human body sets its target blood glucose level – the glycemic set point – and say their findings could have implications for ongoing diabetes research and the development of regenerative therapies.   Every animal species has its own signature glycemic set point, andRead more
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Mar 09,2018
Diarrheal Disease Protection May Literally Be within Spitting Distance
While it's not typically desirable to think about saliva and diarrhea in the same context, a new study led by investigators at the Boston University School of Medicine (BUSM) may have just uncovered a role for a family of salivary peptides in defending the body against diarrheal disease. The research team identified a protein inRead more
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Diarrheal Disease Protection May Literally Be within Spitting Distance
Mar 08,2018
Gene-Therapy Trials for Inherited Form of Blindness Could Start in Two Years
Scientists in the U.S. say human trials of gene therapy for an inherited form of blindness known as vitelliform macular degeneration, or Best disease, could be less than two years away, following successful use of the treatment in a canine model of the disease. Developed through a longstanding collaboration between scientists at the University ofRead more
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Mar 07,2018
Bacteria Resistant to Colistin Present Serious Clinical Challenge
Researchers at Emory Health Sciences have detected “heteroresistance” to colistin, a last-resort antibiotic, in already highly resistant Klebsiella pneumoniae. Their study ("Carbapenem-Resistant Klebsiella pneumoniae Exhibiting Clinically Undetected Colistin Heteroresistance Leads to Treatment Failure in a Murine Model of Infection”) appears in mBio. "Antibiotic resistance is a growing crisis and a grave threat to human health. It isRead more
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Mar 07,2018
CRISPR Human Knockout Screens Identify New Target for ALS
Through genome editing, a team at Stanford University School of Medicine has used CRISPR/Cas9 technology to gain new insights into the genes that might represent new targets for the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and may even protect against the degeneration of neurons. Led by Aaron Gitler, Ph.D., professor of genetics, and Michael Bassik,Read more
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CRISPR Human Knockout Screens Identify New Target for ALS
Mar 07,2018
Protein-Protein Interactions Assay
Why PPI (Protein Protein Interaction)? · Protein-Protein Interactions determine the outcome of most cellular processes · Proteins which are close homologues often interact in the same way · Protein-Protein Interactions place evolutionary constraints on protein sequence and structural divergence · Pre-cursor to networks PPI (Protein Protein Interaction) Classification · Strength of interaction — Permanent orRead more
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Protein-Protein Interactions Assay
Mar 06,2018
Dual Checkpoint Inhibition Boost from New Bifunctional Antibody
Researchers at Johns Hopkins University School of Medicine have developed a new class of bifunctional antibody-based immunotherapy that targets immune checkpoints, but simultaneously disables the production of immunosuppressive regulatory T cells (Tregs). The new molecules, dubbed Y-traps, comprise a Y-shaped antibody fused to a transforming growth factor beta (TGF-β) receptor domain that switches off theRead more
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Dual Checkpoint Inhibition Boost from New Bifunctional Antibody
Mar 06,2018
Heart Tissue Regeneration through Cell Cycle Tweaks
Researchers at the Gladstone Institutes say they have developed an efficient and stable method to make adult cardiomyocytes divide and repair hearts damaged by heart attacks. They published their study ("Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration”) in Cell. "Human diseases are often caused by loss of somatic cells that areRead more
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Heart Tissue Regeneration through Cell Cycle Tweaks
Mar 06,2018
What is Preclinical ADME Studies?
ADME studies–ADME is an abbreviation in pharmacokinetics and pharmacology, stands for absorption, distribution, metabolism and elimination of chemicals and drugs to define the impact in a human body. Toxicology testing is a significant event before an introduction of new drugs into the market. However, drug development is a very crucial stage of the pharmaceutical andRead more
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What is Preclinical ADME Studies?