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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Mar 19,2018
Coffee Consumption Affects Cannabinoid Metabolism
Coffee alters your metabolism in more complex and surprising ways than simply jolting you awake, according to new research. A study from researchers at Northwestern University showed that increased coffee consumption alters more metabolites than previously thought, and decreases those from the body's endocannabinoid system, which processes cannabinoids found in marijuana. Findings from the newRead more
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Coffee Consumption Affects Cannabinoid Metabolism
Mar 16,2018
Treating Obesity with Brown Fat–Related Molecule
While most fat cells in the human body store energy, everyone has a small subset of brown fat cells that do the opposite – burn energy and generate heat. Now, Salk researchers have discovered how the molecule ERRγ, or estrogen-related receptor gamma, gives this "healthier” brown fat its energy-expending identity, making those cells ready toRead more
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Mar 16,2018
Cell Sex a Factor in Nanoparticle Uptake and Efforts to Change Cell Fate
A nanoparticle may have little surface area, but it does represent a wide-open frontier in nanomedicine, which seeks to deploy nanoparticles in imaging, drug delivery, and cell reprogramming applications. In recent years, the discipline has been exploring the nanoparticle's nanobio interface, that is, the composition of the nanoparticle's protein corona.   The nanobio interface, scientistsRead more
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Mar 15,2018
DNA Mapping Finds 110 Genes Linked to Breast Cancer
Scientists at The Institute of Cancer Research, London (U.K.) have used a high-throughput genetic analysis technique known as Capture Hi-C (CHi-C) to link 110 genes with an increased risk of breast cancer. The high-resolution technique can identify how regulatory genetic elements physically interact with distant protein-coding genes, even when separated by megabases (Mb) of DNA.Read more
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DNA Mapping Finds 110 Genes Linked to Breast Cancer
Mar 15,2018
CRISPR Screen Identifies Genetic Modifiers of ALS
While much of the genetics surrounding amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has been enigmatic for decades, new gene-editing techniques – such as CRISPR/Cas9 – are beginning to help uncover genes in the human genome that may modify the severity of these neurological disorders.   Researchers at Stanford University just published their recentRead more
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CRISPR Screen Identifies Genetic Modifiers of ALS
Mar 14,2018
Low-Fat and Reduced-Calorie Diet May Prevent Age-Related Brain Changes
A low-fat diet in combination with limited caloric consumption prevents activation of the brain’s immune cells – called microglia – in aging mice, shows research published in Frontiers in Molecular Neuroscience. The study ("Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging”) also finds that exercise is significantly less effective than caloric restrictionRead more
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Mar 14,2018
Genes Play A Role In Empathy
Genetics plays a role in people's empathy — in addition to education and experience — and could help researchers and doctors better understand autism, according to a large study.   A study by scientists in the U.K., France, and the U.S. suggests that the degree of empathy we feel toward our fellow man is atRead more
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Genes Play A Role In Empathy
Mar 13,2018
Genetic Origins of the Sexes Found to be Surprisingly Modest
Studies in green algae have generated some surprising new findings on the genetic changes that might have underpinned the evolution of male and female gametes. While prior studies in both animals and plants suggest that large-scale genetic expansion and differentiation must have occurred to enable the divergence of male and female chromosomes, new research inRead more
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Mar 13,2018
CRISPR Use Creates Malaria-Resistant Mosquitoes
Malaria continues to be a scourge on the human population, leading to hundreds of thousands of deaths each year. While the complex life cycle of the parasite that causes malaria can aid its persistence and genetic diversity, it also allows for potentially multiple therapeutic target areas. Many researchers focus their attention on the parasite’s forayRead more
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Mar 12,2018
Pregnancy Obesity Alters Fetal Liver Epigenetics and Metabolic Pathways
Could a mother's diet and excess weight during pregnancy predispose her offspring to become obese and develop metabolic disorders and cardiovascular diseases later in life? U.S. researchers report on new molecular and genetic studies in baboons that support existing epidemiological evidence suggesting that maternal obesity (MO) may "preprogram” offspring to develop cardiometabolic diseases in adulthoodRead more
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Pregnancy Obesity Alters Fetal Liver Epigenetics and Metabolic Pathways