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Hot information：
Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Apr 09,2018
Caloric Restriction Increases Lifespan But Affects Brain Integrity
Scientific evidence continues to mount in support of the hypothesis that reducing overall calorie intake, while still maintaining a balanced diet, leads to a significant increase in lifespan. Previous research – for macaques, in particular (which have an average lifespan of forty years) – had already demonstrated the beneficial effect on the incidence of age-relatedRead more
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Apr 06,2018
Stem Cells Given Tough Love Are More Eager to Form Adult-Like Heart Tissue
Growing human cardiac tissue that behaves like native heart muscle would be transformative for biomedical research, enabling researchers to study human physiology and model heart diseases under fully controlled conditions. While today scientists can grow many tissues, including the heart muscle, from stem cells taken from a small blood sample of any of us, currentRead more
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Apr 06,2018
DNA Mimics that Inhibit DNA-Protein Interactions May Lead to Novel Therapeutics
DNA, the central molecule of life, carries genetic information organized in the two complementary strands of its double helix. In order for this genetic information to be read and executed, or on the contrary to prevent or regulate its expression, a number of proteins interact with DNA, for example by "binding” to the negative chargesRead more
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Apr 05,2018
Cancer Metabolism Link with Breast Cancer Oncogene
Scientists have identified a molecule that connects a biochemical pathway used by cancer cells to generate energy and regulates an oncogene that drives the progression of breast cancer and other tumor types. The studies, by a team at Baylor College of Medicine and Roswell Park Comprehensive Cancer Center, showed that PFKFB4, an enzyme in theRead more
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Cancer Metabolism Link with Breast Cancer Oncogene
Apr 05,2018
Some DNA-Binding Enzymes Prefer Fake DNA to the Real Thing
They're not DNA molecules, but they have the curves and folds they need to fool DNA-binding enzymes. If these DNA mimics can be twisted just so, they may turn out to be useful decoys, capable of misleading the enzymes deployed by human immunodeficiency virus (HIV) and other viruses. A class of DNA mimics consisting ofRead more
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Apr 04,2018
Cancer Can Be Driven by Noncoding DNA Mutations
Most of the human genome – 98 percent – is made up of DNA but doesn't actually encode genes, the recipes cells use to build proteins. The vast majority of genetic mutations associated with cancer occur in these non-coding regions of the genome, yet it's unclear how they might influence tumor development or growth. ScientistsRead more
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Cancer Can Be Driven by Noncoding DNA Mutations
Apr 04,2018
Congenital Heart Defects in Offspring Elevate Maternal Cardiac Disease Risk
Using newborns as a long-term gauge for maternal cardiac health may seem like a far-fetched idea, but a new study from investigators at McGill University and the University of Montreal Hospital Research Center has found that women who give birth to infants with congenital heart defects may have an increased risk of cardiovascular hospitalizations laterRead more
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Congenital Heart Defects in Offspring Elevate Maternal Cardiac Disease Risk
Apr 03,2018
Immunotherapy Calls Up Natural Killer Cells in the Fight against Cancer
Cancer immunotherapy frequently goads T cells to fight cancer more zealously, and now it is starting to demand more of natural killer (NK) cells, too. All too often, NK cells find themselves on the sidelines, fooled by tumor cells that shed the stress proteins that would otherwise serve as "kill me” signals. But what ifRead more
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Immunotherapy Calls Up Natural Killer Cells in the Fight against Cancer
Apr 03,2018
Gonorrhea Superbug Evades Immune System by Creating Vesicles That Attack Macrophages
Scientists at Monash University say they discovered how the gonorrhea superbug evades the immune system, opening up a way for therapies that prevent this process and allowing the body's natural defenses to kill the bug.
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Gonorrhea Superbug Evades Immune System by Creating Vesicles That Attack Macrophages
Apr 02,2018
Vitamin Precursor Could Help Reverse Cardiovascular Aging Effects
New findings from investigators at the University of Colorado Boulder indicate that when people consume a natural dietary supplement and precursor to vitamin B3 called nicotinamide riboside (NR) daily, NR mimics caloric restriction (CR) and kick-starts the same key chemical pathways responsible for its health benefits. Findings from the new study were released in NatureRead more
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