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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Apr 13,2018
Highly Sensitive Detection of Hepatitis B Using ddPCR
Developing new, more sensitive assays to detect chronic infections, like those from the hepatitis B virus (HBV), is imperative to when trying to manage associated diseases such as cirrhosis and hepatocellular carcinoma (HCC).   Now, a new study from investigators at the Center for Gene Diagnosis in the Zhongnan Hospital of Wuhan University, China, describesRead more
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Apr 13,2018
Brain Mitochondrial Iron Found to Accumulate in Huntington's Disease
University of Wyoming researchers say they have found that mice engineered to have Huntington's disease (HD) have an over-accumulation of iron in their mitochondria. Their work identifying a pathway for the neurodegenerative disease also has relevance to understanding related disorders such as Parkinson's, Alzheimer's, and Lou Gehrig's diseases, says Jonathan Fox, Ph.D., a professor in theRead more
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Brain Mitochondrial Iron Found to Accumulate in Huntington's Disease
Apr 12,2018
Therapeutic Vaccine Suppresses Peanut Allergies
In recent years, the number of nut allergies has skyrocketed. While the theories behind the specific origins for this spike are numerous and often controversial, the physiological effects are real and for many, potentially life-threatening. Due to the real need for clinical intervention, many researchers have been on the hunt to develop therapies that canRead more
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Apr 12,2018
Biomarkers Can Predict Risk Level for Malignant Glioma Recurrence
Researchers have identified specific predictive biomarkers that could help assess the level of risk for recurrence in patients with malignant glioma. The study ("A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence”), led by Henry Ford Health System's Department of Neurosurgery and Department of Public Health Sciences,Read more
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Biomarkers Can Predict Risk Level for Malignant Glioma Recurrence
Apr 11,2018
Mitochondrial Protein Alterations May Underlie Inflammatory Myopathies
The link between mitochondria and inflammation is still unclear. But it is known is that the accumulation of defective mitochondria that should have been removed causes inflammation.   Scientists at the Institute for Research in Biomedicine (IRB), in Barcelona, report that the removal of a single mitochondrial protein in mouse muscle leads to severe inflammationRead more
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Mitochondrial Protein Alterations May Underlie Inflammatory Myopathies
Apr 11,2018
Regular Exercise Can Beat Genetic Factors For Heart Diseases
The investigators found that people with higher levels of grip strength, physical activity, and cardiorespiratory fitness had reduced risks of heart attacks and stroke, even if they had a genetic predisposition for heart disease.
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Regular Exercise Can Beat Genetic Factors For Heart Diseases
Apr 11,2018
How to do stability research? ICH Q1 has the answer
[Guide] ICH Q1: Stability Research Let us further understand an important result of ICH, namely the Guideline. Starting today, let's understand the quality part (ICH-Q) of one of the four major categories. 1. Overview of the composition and content of ICH Q First, let's take a look at the ICH quality guidelines as a whole,Read more
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How to do stability research? ICH Q1 has the answer
Apr 10,2018
Immunotherapy Combo for Metastatic Lung Cancer Shows Success
We've come to the point in modern medicine where a single compound to treat a complex disease like cancer has become increasingly less of an option. However, on the positive side, the number of successful combination therapies continues to grow. For instance, results from a new clinical trial by investigators at the Hollings Cancer Center,Read more
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Apr 10,2018
Novel Antibiotics Could Arise from Adhesion Protein Structure Analysis
Researchers at Harvard Medical School, the University of California-San Francisco, and the University of Georgia have described how the protein that allows strep and staph bacteria to stick to human cells is prepared and packaged.   Their study ("Unraveling the sequence of cytosolic reactions in the export of GspB adhesion from Streptococcus gordonii”), which couldRead more
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Apr 09,2018
Drug-Resistant Pneumonia Sensitive to Neutrophil Modulation
An increasing problem in cases of bacterial pneumonia is antibiotic resistance. While immune-stimulating therapies can help the body kill the bacteria, they can also cause inflammation that damages and weakens lung tissue.   In a paper ("Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia”) in Science Translational Medicine, researchers at Boston Children’s Hospital describe a techniqueRead more
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