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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Apr 20,2018
Immunological Memory Dependent Upon Single Transcription Factor
Memory T cells are a critical element of our immune system's historical archive. To prevent repeat infections, these cells retain a record of germs they've fought before.   Immune cell memory is a critical line of defense for the body against repeat infections. Yet, for all their importance, the origins of memory T cells haveRead more
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Immunological Memory Dependent Upon Single Transcription Factor
Apr 20,2018
Gene-Drug Interaction Map Developed to Aid Personalized Chemotherapy
Despite the great successes of targeted cancer drugs and the promise of novel immunotherapies, the vast majority of people diagnosed with cancer are still first treated with chemotherapy. Now, a new study using techniques drawn from computational biology could make it much easier for physicians to use the genetic profile of a patient's tumor toRead more
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Gene-Drug Interaction Map Developed to Aid Personalized Chemotherapy
Apr 19,2018
Novel Research Model Offers Hope to ALS and MS Patients
Scientists at the Karolinska Institute in Sweden have developed a new disease model for neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) that can be used to develop new immunotherapies. The model is described in a paper ("Fatal Demyelinating Disease Is Induced by Monocyte-Derived Macrophages in the Absence of TGF-β Signaling”) in NatureRead more
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Apr 19,2018
Human Brain Organoids Thrive in Mouse Brains
Brain organoids, also known as mini-brains, are tiny clumps of brain cells grown from stem cells that researchers are using to investigate the neural underpinnings of autism and other neurological disorders. But the organoids typically grow in culture for only a few months before they die, limiting their usefulness as models of real brains.  OrganoidsRead more
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Apr 18,2018
Mitochondria Choked with Proteins Can Activate Gag Reflex
When the cell tries to stuff too many proteins into its mitochondria, protein blockages and backups may result – obstructions for which no cell-level version of the Heimlich maneuver is available. Instead of putting a physical squeeze on its energy-producing organelles, the cell resorts to another mechanism – mitoCPR, or the mitochondrial compromised protein importRead more
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Apr 18,2018
Blood Pressure Drugs Work Best with Musical Accompaniment
Listening to music heightens the beneficial effects of blood pressure–lowering drugs, according to the results of a study by scientists in Brazil and the U.K. The team, coordinated by Vitor Engrácia Valenti, Ph.D., a professor in the Speech Language Pathology Department of UNESP Marília’s School of Philosophy & Sciences (FFC) in Brazil, found that hypertensionRead more
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Apr 17,2018
Soluble Antibodies Play Immune Suppressive Role in Tumor Progression
Scientists at the Wistar Institute have found that soluble antibodies promote tumor progression by inducing accumulation of myeloid-derived suppressor cells (MDSCs) in preclinical cancer models. Their study ("Secretory IgM Exacerbates Tumor Progression by Inducing Accumulations of MDSCs in Mice”) appears in Cancer Immunology Research. "Chronic lymphocytic leukemia (CLL) cells can secrete immunoglobulin M. However
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Soluble Antibodies Play Immune Suppressive Role in Tumor Progression
Apr 17,2018
CRISPR Combines with Gene Delivery System to Create Brain Tumor Model
In animal models, disease recapitulation is the guiding principle. Scientists spend considerable time and effort trying to reproduce – as closely as possible – the exact molecular and physiological conditions associated with various diseases states. To that end, a new study from investigators at the Seve Ballesteros Foundation-CNIO Brain Tumor Group at the Spanish NationalRead more
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CRISPR Combines with Gene Delivery System to Create Brain Tumor Model
Apr 16,2018
“Sweet Tooth” Gene Variant Associated with Lower Body Fat
A common variant of the gene for the liver hormone fibroblast growth factor 21 (FGF21) genetically predisposes carriers to eat more sugar and consume more alcohol, but it is also, perhaps counterintuitively, associated with lower total body fat, according to the findings of a study headed by researchers at the University of Exeter in theRead more
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Apr 16,2018
Personalized Cancer Vaccine Shows Promise in Patients with Advanced Ovarian Cancer
Ovarian cancer is a particularly hard-to-treat disease. It's often diagnosed late, and even after surgery and chemotherapy, around 85 percent of patients relapse and develop chemoresistance.   A new kind of personalized vaccine – one made by exposing a patient's own immune cells to the contents of a patient's own tumor cells – has beenRead more
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