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Hot information：
Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
May 25,2018
RNA Sequencing Identifies Liver Genes Malaria Exploits for Survival
Once transmitted from infected mosquitoes, malaria parasites make a beeline toward the host's liver to evade immune detection and set up camp. Inside the liver cells, the parasite rapidly reproduces, copying itself as many as 30,000 times in the span of 48 hours. After building strength in numbers, the parasite leaves the liver and escapesRead more
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May 24,2018
Cell Network Study Shines Light on Lung Cancer Signal Pathways
Researchers say they have identified networks inside lung cancer cells that will help understand this cancer and fight it with drug treatment. Their study ("Integration of Protein Phosphorylation, Acetylation, and Methylation Data Sets to Outline Lung Cancer Signaling Networks”), published in Science Signaling, sheds light on how HSP90 inhibitors, which are currently in clinical trials, workRead more
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May 24,2018
Biogel Promotes Brain Tissue Growth and Limb Recovery after Stroke in Mice
U.S. scientists have developed a bioengineered gel that can promote the growth of new blood vessels and neurons in stroke-damaged mice, resulting in what researchers call "dramatic” improvements in limb function.   Scientists at the University of California, Los Angeles (UCLA), and Duke University developed an immune-modulating angiogenic gel containing vascular endothelial growth factor (VEGF)Read more
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May 23,2018
Tumor-Suppressor Genes Turned Off by 3′ UTR Shortening
Researchers say they have uncovered new information that more accurately explains how cancerous tumors grow within the body. Their study ("3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk”) appears in Nature Genetics. For more details about Medicilon's tumor model. The team, led by scientists at The University of Texas Medical Branch (UTMB) atRead more
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Tumor-Suppressor Genes Turned Off by 3′ UTR Shortening
May 23,2018
CRISPR Eradicates Latent HIV-1, Offering Hope of “Functional Cures”
Scientists in Japan have used CRISPR-Cas9 technology to stop human immunodeficiency virus type 1 (HIV-1) replication in latently infected T cells that can't be controlled using existing drug treatments. The gene-editing approach effectively disrupts two regulatory HIV-1 genes, tat and rev, which are essential for viral replication. Describing their in vitro studies in Scientific Reports,Read more
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May 22,2018
RNA Gets Large-Scale Structural Analysis and Annotation Tool
DNA has often overshadowed its single-stranded brethren in many aspects of molecular biology, but as technology continually improves, allowing researchers to manipulate this complex molecule, we are beginning to understand just how vital RNA is on the daily cellular level, as well as its impact on disease.   Now, researchers at Oregon State University (OSU)Read more
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RNA Gets Large-Scale Structural Analysis and Annotation Tool
May 22,2018
IBD Triggered by Gut Microbes and Dietary Compounds
Researchers in the U.S. and U.K. have uncovered a link between an antimicrobial toxin that is produced by common gut bacteria to fend off their rivals and inflammatory bowel disease (IBD). The studies more broadly discovered that, in addition to the well-studied microbial toxin microcin B17, structurally related compounds that are found in many foodsRead more
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IBD Triggered by Gut Microbes and Dietary Compounds
May 21,2018
Noncoding RNA Drug Target for Colon Cancer Discovered
Long noncoding RNAs (lncRNAs) are, as the name suggests, long transcripts of RNA that do not code for proteins, but have been found to regulate a wide range of cell functions. Scientists at Case Western Reserve School of Medicine have now discovered that one lncRNA, designated lincDUSP, may play a role in initiating colon cancerRead more
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Noncoding RNA Drug Target for Colon Cancer Discovered
May 21,2018
Marijuana Treatment Reduces Severe Epileptic Seizures
The psychotropic effects of cannabis may be what the historically maligned drug is best known for, yet in recent decades a growing body of evidence continues to suggest that the drug has numerous valuable properties that make it a potentially valuable therapeutic.   Now, investigators from NYU School of Medicine have shown in a newRead more
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Marijuana Treatment Reduces Severe Epileptic Seizures
May 18,2018
Targeting Colon Cancer Plasticity May Prevent Drug Resistance
Scientists in Germany have discovered that colon cancers contain two different cell types, characterized by mitogen-activated protein kinase (MAPK) and NOTCH signaling, respectively, which can regenerate each other when one type is killed by a targeted therapeutic. The studies, headed by David Horst, Ph.D., at the Charité University Hospital in Berlin, suggest that this cellRead more
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Targeting Colon Cancer Plasticity May Prevent Drug Resistance
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