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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jun 14,2018
Immunotherapy Biomarker Predicts Lung Cancer Response and Survival
Immunotherapy changes a patient's immune system to allow it to attack cancer cells and either destroy them or at least keep them from growing. But the therapy only works for a minority of patients.   Now, researchers supported by the Swiss National Science Foundation (SNSF) have discovered how to better predict who will respond toRead more
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Jun 14,2018
Addicted to Aggression? Brain Protein May Hold the Answer
With apologies to Homer Simpson, we might prepare ourselves to hear, "It's true! I'm an aggression-holic! I just can get enough aggression-hol!” Such a confession would be in keeping with a new neuroscientific finding – a protein known to accumulate in the brain's reward center in response to pleasurable experiences, such as sex and otherRead more
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Addicted to Aggression? Brain Protein May Hold the Answer
Jun 13,2018
“Surgery in a Pill” Developed to Mimic Benefits of Bariatric Surgery on Type 2 Diabetes
Over the last decade, bariatric surgeons have made strides in performing weight loss surgery that not only reverses obesity but can also reverse type 2 diabetes in patients with both conditions. Despite dramatic improvements in quality of life and diabetes remission, the number of patients who pursue surgery remains relatively low.   Gastric bypass surgeryRead more
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Jun 13,2018
New DNA Test May Predict Prostate Cancer Risk
New testing strategies for prostate cancer, including noninvasive saliva tests, may be close to hand, now that an in-depth study of DNA samples from more than 140,000 men has implicated 63 additional genetic variants in prostate cancer risk. By adding the newfound variants to previously known prostate cancer risk variants, scientists based at the InstituteRead more
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Jun 12,2018
Tumor Biology Study Suggests Promising New Route to Cancer Drug Development
Scientists at the Babraham Institute say they have shown that some tumors use not one but two levels of protection against the immune system. Knocking out one level boosted the protective effects of the second and vice versa. The research demonstrates that a two-pronged approach targeting both cell types simultaneously may offer a promising routeRead more
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Tumor Biology Study Suggests Promising New Route to Cancer Drug Development
Jun 12,2018
Probiotic Shot May Alleviate Brain Stress
Stress can lead to anxiety and symptoms of depression, which are caused, in part, by neuroinflammatory processes. Studies in mice by a team at the University of Colorado Boulder have now shown how injections of the bacterium Mycobacterium vaccae can prevent these stress-related inflammatory responses in the brain and reduce stress-induced anxiety behavior. Reporting in theirRead more
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Jun 11,2018
Breathing Paralysis Improved through Transplantation of Lab-Grown Neurons
The use of stem cells after spinal cord injury to repair damaged neurons and improve the function of paralyzed neural pathways continues to show promise as a potential future therapy.   Now, researchers from Drexel University College of Medicine and the University of Texas at Austin improved respiratory function in rodents with spinal cord injuriesRead more
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Breathing Paralysis Improved through Transplantation of Lab-Grown Neurons
Jun 11,2018
Antibody Offers New Approach to Treating Inflammatory Diseases
Researchers at the University of California San Diego (UCSD), School of Medicine discovered that they can block inflammation in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardeningRead more
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Antibody Offers New Approach to Treating Inflammatory Diseases
Jun 08,2018
Human Glutamine Transporter Study May Generate Leads for Drug Development
The human glutamine transporter ASCT2 is upregulated in several forms of cancer. It is also the docking platform for a wide range of pathogenic retroviruses. Researchers at the University of Groningen say they have used cryo-electron microscopy to elucidate the structure of the human glutamine transporter ASCT2, which may generate leads for drug development. The results ("Cryo-EM StructureRead more
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Jun 08,2018
Colon Stem Cells Rely on This Repair Signal, but It Can Go Awry
For want of a colonic stem cell niche, colonic stem cells are lost. For want of colonic stem cells, colonic epithelial integrity is lost. For want of colonic epithelial integrity, life is lost. So, the message is clear. Maintain a healthy colonic stem cell niche or suffer grave consequences.   Although the colonic stem cellRead more
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