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Hot information：
Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jul 20,2018
Why Flu Recovery Is Slower for Women
The susceptibility and recovery from various pulmonary infections have been observed to have a sex bias, depending on the microbial pathogen. For instance, researchers have known that women, compared to men, tend to have more severe flu with slower recoveries even when their virus levels are the same. It had been thought that this wasRead more
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Jul 19,2018
Leukemia Cells Take the Fast Track to the Nervous System
Acute lymphoblastic leukemia (ALL) in the central nervous system (CNS) is very difficult to treat, because most drugs are blocked from the organ system due to a "blood-brain barrier” (BBB) designed to protect the brain. How cancer cells enter the central nervous system has been an unanswered question for researchers and clinicians for decades.  Read more
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Leukemia Cells Take the Fast Track to the Nervous System
Jul 19,2018
Cancer's Grip May Be Loosened by Tampering with DNA Clamp
To trip up fast-proliferating cancer cells, try throwing a wrench in their proliferation machinery, the aptly named proliferating cell nuclear antigen (PCNA). Wielding a new kind of wrench, a drug-like protein called a peptidomimetic ligand, scientists based at the University of Adelaide have jammed PCNA more effectively than scientists who have deployed more conventional drugs.Read more
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Jul 18,2018
Weight-Loss Drug Looks to Spice Things Up
Anecdotal stories of spicy foods contributing to weight loss have circulated through the population for many years. In recent years, researchers have begun to tease out the molecular mechanisms that regulate the "hot” effect caused by peppers in the chili family – uncovering the possibility of some credence behind those weight loss stories.   Now,Read more
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Jul 18,2018
Biomarker´s Potential for Diagnosing Traumatic Brain Injury Solidified
Traumatic brain injury (TBI) is characterized by impairments in cognition, emotion, or physical function caused by a violent blow to the head or direct brain penetration by an object. Upon injury, it is often difficult to evaluate the extent of damage or predict how long the impairment will last or whether it will worsen.
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Biomarker´s Potential for Diagnosing Traumatic Brain Injury Solidified
Jul 17,2018
Fragile X Symptoms May be Helped with New Pharmacological Approach
Scientists report that a pharmacological strategy can alleviate multiple behavioral and cellular deficiencies in a mouse model of fragile X syndrome (FXS), the most common inherited form of intellectual disability and a major single-gene cause of autism spectrum disorders. The study ("Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in aRead more
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Jul 17,2018
Cancer Drug Effectiveness Evaluated Using New Methodology
When it comes to anti-cancer drugs, it's not only their effectiveness at killing the intended target that we want to know, but also their ability to reach and penetrate the cancer cells. Researchers report the development of a technique that allows them to measure how well cancer drugs reach their targets inside the body.
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Cancer Drug Effectiveness Evaluated Using New Methodology
Jul 16,2018
Human DNA Sentry Keeps Long Strands Atop Watch List
The human body is built for survival. Each one of its cells is closely guarded by a set of immune proteins armed with nearly foolproof radars that detect foreign or damaged DNA.   Out-of-place DNA arouses the suspicion of a mammalian protein called cGAS, or cyclic GMP-AMP synthase. Although cGAS is usually as passive asRead more
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Human DNA Sentry Keeps Long Strands Atop Watch List
Jul 16,2018
Deletion of Addiction Gene Keeps Mice off Cocaine
Cocaine can have a devastating effect on people.  It directly stimulates the brain's reward center, and, more importantly, induces long-term changes to the reward circuitry that are responsible for addictive behaviors.   European researchers have discovered how a gene that has previously been implicated in cancer plays a key role in certain regions of theRead more
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Jul 13,2018
Immunotherapy Boosts Survival Rates of Melanoma Brain Metastases' Patients
A team led by researchers at Brigham and Women's Hospital reports that checkpoint blockade immunotherapies provided significant improvements in overall survival for patients with melanoma brain metastases. Their results ("Improved Risk-Adjusted Survival for Melanoma Brain Metastases in the Era of Checkpoint Blockade Immunotherapies: Results from a National Cohort”) are published in Cancer Immunology Research.   "The successesRead more
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