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Hot information：
Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Aug 30,2018
Dream Genes Needed for REM Sleep
Sleep is known to allow animals to re-energize themselves and consolidate memories. Rapid eye movement (REM) sleep is known to play an important role in maintaining a healthy mental and physical life, but the molecular mechanisms behind this state are barely understood. We are such stuff as dreams are made on, and that stuff includes Chrm1 and Chrm3,Read more
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Aug 29,2018
Cancer's Last Gasp? Could Be, If Hypoxia Pathway Is Blocked
Low-oxygen conditions ought to suffocate cells, but somehow cancer cells survive. They even progress and spread more aggressively, thanks to a newly identified signaling pathway, the HIF-GPRC5A-YAP axis. Blocking this pathway, scientists suggest, could choke cancer. The pathway appears to be "druggable” because it depends on a G protein-coupled receptor (GPCR), a type of receptorRead more
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Cancer's Last Gasp? Could Be, If Hypoxia Pathway Is Blocked
Aug 29,2018
Melanoma Combo Immunotherapy Increases Toll for Improved Efficacy
Researchers are constantly on the hunt to improve the immune systems' response to tumor cells and are beginning to combine immunotherapy drugs for an even greater response to cancer cells.   Now, investigators from the Geffen School of Medicine at UCLA and Dynavax Technologies have just published data from a Phase Ib study looking atRead more
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Aug 29,2018
Medicilon completes cardiac safety evaluation services
Cardiac safety evaluation is an important factor that must be investigated before various new drugs enter clinical trials, and it is also one of the most important and difficult links in the early clinical research of innovative drugs. The QT interval of the heart refers to the period from the beginning of the QRS complexRead more
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Medicilon completes cardiac safety evaluation services
Aug 28,2018
Novel Approach Stops Immune Cell Death Associated with Multiple Diseases
Researchers from Case Western Reserve University School of Medicine have discovered a way to stop immune cell death associated with multiple diseases, including sepsis, inflammatory bowel disease (IBD), and arthritis. Their study ("Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis”), published in Science Immunology, identified a chemical that potently inhibitsRead more
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Aug 28,2018
Molecular Link Between Aging and Neurodegeneration
For decades researchers have worked to shed light on the causes of neurodegenerative disorders, a group of devastating conditions, including Alzheimer's and Parkinson's, that involve the progressive loss of neurons and nervous system function. In recent years, numerous factors, from genetic mutations to viral infections, have been found to contribute to the development of theseRead more
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Molecular Link Between Aging and Neurodegeneration
Aug 27,2018
Newly Discovered Immune System Micro-organ Could Aid Better Vaccine Development
Scientists at the Garvan Institute of Medical Research in Sydney, Australia, have identified a previously unknown micro-organ within the immune system, which could lead to new approaches for developing more effective vaccines. Discovered in mice using a live imaging technique known as two-photon microscopy, the thin, flattened structures, given the name subcapsular proliferative foci (SPF), Read more
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Aug 27,2018
New Cancer Immunotherapy Activates Necroptosis Mechanisms
While traditional chemo- and radiotherapeutic interventions are effective in reducing tumor size, they unfortunately also affect healthy cells. For decades, scientists have known that the immune system is a more accurate weapon that has evolved to recognize and eliminate disease-causing cells. However, until recently researchers have had difficulties activating the immune system to recognize tumors,Read more
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New Cancer Immunotherapy Activates Necroptosis Mechanisms
Aug 24,2018
Universal Flu Vaccine Candidate Effective in Mice
University of Pennsylvania (UPenn) researchers hope to start clinical trials of a universal mRNA flu vaccine within the next two years, on the back of promising results from tests in multiple animal models. Unlike traditional vaccines that need to be reformulated every year to match mutated viral proteins and different viral strains, the new lipidRead more
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Aug 24,2018
Natural Sugar Could Curb Diabetes
New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces fat accumulation and weight gain, and lessens measures of fats and cholesterol in theRead more
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