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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Nov 15,2018
Engineered DNA-Encoded mAbs Successfully Target Zaire Ebolavirus
Researchers at The Wistar Institute and colleagues say they have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Their study ("In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model”), published online in Cell Reports, showed that DMAbs were expressed overRead more
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Engineered DNA-Encoded mAbs Successfully Target Zaire Ebolavirus
Nov 14,2018
High-Protein Diet Exposes Cancer Stem Cells to New Drug Approach
Unlike healthy cells or mature cancer cells, the stem cells that sustain cancer rely on energy derived from protein or, more precisely, amino acids. This unique dietary preference, say scientists based at the University of Colorado Cancer Center, makes cancer stem cells uniquely vulnerable to drugs that inhibit amino acid uptake. Such drugs could killRead more
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Nov 14,2018
Gut Microbiome Bacteria Provides Link Between Fiber and Heart Health
Fiber, fiber, and more fiber! If you want to have a healthy gut and strong heart you must eat your fiber – at least that's what the inundating marketing campaigns tell us on a daily basis. Thankfully, most scientific evidence also currently supports that diets rich in fiber are associated with an array of positiveRead more
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Gut Microbiome Bacteria Provides Link Between Fiber and Heart Health
Nov 13,2018
Autism-Zinc Link Mechanistically Defined
Researchers say they have defined a possible mechanistic link that explains how zinc deficiency could contribute to autism. Their study ("Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons”), published in Frontiers in Molecular Neuroscience, shows how zinc shapes the synapses between brain cells that form during early development, via a complexRead more
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Nov 13,2018
Asymptomatic Brain Injury Linked to Atrial Fibrillation
Researchers from the Intermountain Medical Center Heart Institute in Salt Lake City have found that patients with atrial fibrillation (AF) also show signs of asymptomatic brain injury. They reported the results of their study at the American Heart Association Scientific Session conference in Chicago.   The team enrolled 246 patients in the study: 198 with atrialRead more
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Nov 12,2018
Team Shows How Cancer Suppressor AMPK Can Also Help Tumors Grow
Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer. For more details about Medicilon's tumor model. The lab of Reuben Shaw, Ph.D., director ofRead more
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Team Shows How Cancer Suppressor AMPK Can Also Help Tumors Grow
Nov 12,2018
Chlamydia Attacks with Frankenstein Protein
Scientists at the MRC Laboratory of Molecular Biology in the U.K., and Duke University in the U.S., report new insights into the mechanisms by which the pathogenic bacterium Chlamydia trachomatis hijacks the human host cells in which it replicates. Their finding, which they say "unveils a remarkable case of protein moonlighting,” suggests that one ChlamydiaRead more
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Nov 09,2018
Response to Immunotherapy Predicted by Extracellular Matrix Genes
Immunotherapy has been a life-saving intervention for an array of diseases, particularly cancer. However, the treatments are not suited for every patient and can lead to serious side effects and even death. Understanding which patients would be best served by immunotherapy treatments is quickly becoming an essential factor in designing treatment strategies. As such, investigatorsRead more
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Nov 09,2018
CRISPR-Cas9 without Donor Templates Still Accomplishes DNA Repair
CRISPR-Cas9 has the reputation for being "snip happy,” for cutting and cutting a genomic site until one of the cell's DNA repair systems finally skips a beat, leaving the site imperfectly repaired – scarred, really. Although scarred DNA has its purposes, it isn't the same thing as precisely edited DNA. According to a new studyRead more
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Nov 08,2018
Drug-Resistant Bacteria May Succumb to Antibiotic-Polypeptide Conjugates
Peptides and proteins incorporating an unusual amino acid, selenocysteine, easily conjugate with small molecules – including antibiotics to which bacteria have become resistant. Fortunately, selenocysteine appears capable of giving such antibiotics an extra boost, report scientists based at MIT. These scientists showed that a selenocysteine-containing peptide enhanced the effectiveness of the antibiotic vancomycin against twoRead more
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Drug-Resistant Bacteria May Succumb to Antibiotic-Polypeptide Conjugates