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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Nov 30,2018
Cancer Drug Discovery Gets Boost from Novel Proteomics Platform
Scientists at the Van Andel Research Institute have developed a novel biochemical platform to research a family of enzymes that are promising targets for cancer treatment. The study ("A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity”), published in Science Advances, describes a new method that provides a high-resolution view of howRead more
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Cancer Drug Discovery Gets Boost from Novel Proteomics Platform
Nov 29,2018
Staph Genes That Turn Commensal to Killer Identified
Don't be alarmed, but a bacterium that could turn deadly is on your skin right now. This bacterium, Staphylococcus epidermis, is usually harmless, but it may harbor genes that could help it exploit any opportunity to grow in your bloodstream. Once there, it could shrug off your immune response, resist the antibiotics you receive, andRead more
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Nov 29,2018
Method Predicts Exact Mutations CRISPR Gene Editing Can Introduce into a Cell
The largest study of CRISPR action to date has developed a method to predict the exact mutations CRISPR-Cas9 gene editing can introduce to a cell. Researchers at the Wellcome Sanger Institute edited 40,000 different pieces of DNA and analysed a thousand million resulting DNA sequences to reveal the effects of the gene editing and developRead more
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Method Predicts Exact Mutations CRISPR Gene Editing Can Introduce into a Cell
Nov 28,2018
Two-Pronged Approach Shows Promise against Drug-Resistant Cancers
Researchers at the University of California, San Francisco (UCSF) report that they have discovered why some lung cancers become drug-resistant after initially responding to targeted therapies. In the process, they say they devised a new two-pronged approach that yields an effective treatment for these cancers in the laboratory and holds promise for the future ofRead more
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Two-Pronged Approach Shows Promise against Drug-Resistant Cancers
Nov 28,2018
Brown Fat-Boosting Protein Points to Safer Anti-Obesity Strategies
An international team of scientists has identified a protein that boosts the energy-burning activity of brown fat in mice, and which could feasibly lead to the development of new therapeutic approaches for treating obesity in humans. The research, headed by a team at the University of Cambridge, U.K., showed that the protein, BMP8b, effectively superchargesRead more
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Nov 27,2018
Universal DNA Database Could Keep Police Investigations in Bounds
Imagine a DNA database populated with data from every individual in society and made available to law enforcement. Such a database sounds ominous, especially if you've watched Black Mirror or similarly dystopian-themed programs. But such a DNA database could also be reassuring, suggests a team of scientific and policy experts at Vanderbilt University. According toRead more
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Nov 27,2018
35 Genes Shape Risk to Chronic Kidney Disease
Understanding the genetic makeup of complex chronic diseases is a significant step toward developing advanced diagnostics and better treatment options. In that vein, an international team of investigators led by scientists at the University of Manchester put together an extensive genome-wide association study (GWAS) to identify the genetic factors that predispose people to chronic kidneyRead more
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Nov 26,2018
Cancer Cells Stopped from Metastasizing along Highways in Tumors
Researchers at the University of Minnesota have developed a technique to stop cancer cells from moving and metastasizing. The discovery could have a major impact on millions of people undergoing therapies to prevent the spread of cancer within the body, according to the scientists.   It's been known for years that tumors have patterns thatRead more
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Nov 26,2018
African Sleeping Sickness Lifecycle Secrets Revealed
The tiny Teste fly has been a scourge for centuries in many parts of Africa, spreading the debilitating and even deadly disease called African sleeping sickness. Now, investigators from Clemson University have released new findings focusing on the biological cues that signal the parasite which causes the disease – Trypanosoma brucei – to change lifeRead more
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African Sleeping Sickness Lifecycle Secrets Revealed
Nov 21,2018
Lung Cancer Treatment Approach May Support Disease Progression
Epigenetic regulators that modify factors involved in switching genes on and off represent attractive anticancer targets, but whether this strategy will work in vivo hasn't yet been proven. Studies in mice by researchers headed by a Boston Children's Hospital team now suggest that blocking one epigenetic regulator – a histone methyltransferase known as G9a –Read more
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Lung Cancer Treatment Approach May Support Disease Progression