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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Oct 15,2020
The Biological Analysis of Bispecific Atibody
With the development of bispecific antibody technology, bispecific antibody now presents a good development prospect. When major companies are deploying bi-antibody product research and development, they also need to pay attention to the detection and analysis of bi-antibody. Points to note and consider. Dr. Zhang Dengji, Director of Pharmaceutical Analysis Department of Medicilon Biotechnology, broughtRead more
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The Biological Analysis of Bispecific Atibody
Oct 14,2020
Drug absorption, distribution, metabolism and excretion (pharmacokinetics)
Pharmacokinetics (PK), also known as pharmacokinetics, is a discipline that studies the process of drugs in the body, including the changes in the absorption, distribution, metabolism and excretion of drugs and their metabolites over time, and applied kinetics A quantitative description of this process by principles and mathematical processing methods. Pharmacokinetics is a discipline thatRead more
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Drug absorption, distribution, metabolism and excretion (pharmacokinetics)
Oct 14,2020
High-throughput ADME research in the new drug discovery phase
In the past ten years, the cycle of drug discovery and development has become longer and longer, and the cost of testing has increased. In Western countries, it takes 10 to 15 years to develop and market a new compound entity, and it costs more than US$800 million. Of the 10,000 new compound entities, 10Read more
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High-throughput ADME research in the new drug discovery phase
Oct 13,2020
Oncolytic virus and CAR-T open a new way to overcome the problem of solid tumors
Due to the combination of tumor and CAR-T immunotherapy, the amazing results produced are exciting. Medicilon followed closely with international companies in tumor models, especially in the field of immune tumor animal model evaluation systems, and introduced internationally advanced PET-CT imaging systems, radiotherapy radiation systems, IVIS small animal imaging systems, multi-channel flow cytometry analyzers, etc.Read more
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Oncolytic virus and CAR-T open a new way to overcome the problem of solid tumors
Oct 10,2020
NAM: The nemesis of glaucoma struck, helping patients stay away from the “thief” of vision
Glaucoma is the leading cause of irreversible blindness worldwide. This disease causes vision loss when the optic nerve and retinal cells are lost. The etiology of the disease is complex, with a wide range of risk factors. Age, race, family history, myopia, cardiovascular disease, diabetes, abnormal blood rheology, etc. are all risk factors for glaucoma.Read more
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NAM: The nemesis of glaucoma struck, helping patients stay away from the “thief” of vision
Oct 09,2020
PROTAC is first showing its edge, SD-36 has excellent anti-tumor effect
On November 11, the team of Chinese-American Wang Shaomeng published a paper titled "A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo” in the scientific journal Cancer Cell, which immediately stirred up thousands of people. Layers of waves have brought PROTAC technology back to people's sight. Shanghai Medicilon Biopharmaceutical Co.,Read more
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PROTAC is first showing its edge, SD-36 has excellent anti-tumor effect
Oct 09,2020
LYTAC was born, fighting side-by-side with PROTAC to target non-medicable targets
The advent of PROTAC The advent of PROTAC has brought solutions to targets that traditional small-molecule drugs cannot be made into. After 2017, PROTAC technology has developed rapidly, from the laboratory to the industrial world, starting from Harvard University, Yale University, Arvinas, C4, Kymera Therapeutics have been established to specialize in PROTAC technical drug research,Read more
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LYTAC was born, fighting side-by-side with PROTAC to target non-medicable targets
Oct 09,2020
Will vitamin D become a new hope for the prevention and treatment of COVID-19?
The rapid spread of COVID-19 is a public health emergency that has attracted international attention. The clinical situation of COVID-19 is still not fully understood, but it is obviously related to respiratory symptoms, and in some cases it can induce acute multiple organ failure. Respiratory distress syndrome (ARDS), especially in elderly patients with a historyRead more
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Will vitamin D become a new hope for the prevention and treatment of COVID-19?
Sep 30,2020
Science Sub-Journal: A new model can predict the injectability of microparticle formulations
Particulate preparation refers to a solid, liquid, semi-solid or gaseous pharmaceutical preparation composed of particles with a certain particle size (micron or nanometer) made by a certain dispersion and embedding technology with a suitable carrier (generally a biodegradable material) It has excellent properties such as improving the stability of the drug, reducing adverse drug reactions,Read more
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Science Sub-Journal: A new model can predict the injectability of microparticle formulations
Sep 29,2020
[Nature] New treatment plan for non-small cell lung cancer: targeted degradation of EGFR
Lung cancer is one of the most common malignant tumors in the world, and it has become the first cause of death from malignant tumors in the urban population of our country. Non-small cell lung cancer (NSCLC) includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Compared with small cell carcinoma, cancer cells grow andRead more
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[Nature] New treatment plan for non-small cell lung cancer: targeted degradation of EGFR