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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021

The Biological Analysis of Bispecific Atibody

With the development of bispecific antibody technology, bispecific antibody now presents a good development prospect. When major companies are deploying bi-antibody product research and development, they also need to pay attention to the detection and analysis of bi-antibody. Points to note and consider. Dr. Zhang Dengji, Director of Pharmaceutical Analysis Department of Medicilon Biotechnology, broughtRead more

The Biological Analysis of Bispecific Atibody

Drug absorption, distribution, metabolism and excretion (pharmacokinetics)

Pharmacokinetics (PK), also known as pharmacokinetics, is a discipline that studies the process of drugs in the body, including the changes in the absorption, distribution, metabolism and excretion of drugs and their metabolites over time, and applied kinetics A quantitative description of this process by principles and mathematical processing methods. Pharmacokinetics is a discipline thatRead more

Drug absorption, distribution, metabolism and excretion (pharmacokinetics)

High-throughput ADME research in the new drug discovery phase

In the past ten years, the cycle of drug discovery and development has become longer and longer, and the cost of testing has increased. In Western countries, it takes 10 to 15 years to develop and market a new compound entity, and it costs more than US$800 million. Of the 10,000 new compound entities, 10Read more

High-throughput ADME research in the new drug discovery phase

Oncolytic virus and CAR-T open a new way to overcome the problem of solid tumors

Due to the combination of tumor and CAR-T immunotherapy, the amazing results produced are exciting. Medicilon followed closely with international companies in tumor models, especially in the field of immune tumor animal model evaluation systems, and introduced internationally advanced PET-CT imaging systems, radiotherapy radiation systems, IVIS small animal imaging systems, multi-channel flow cytometry analyzers, etc.Read more

Oncolytic virus and CAR-T open a new way to overcome the problem of solid tumors

NAM: The nemesis of glaucoma struck, helping patients stay away from the “thief” of vision

Glaucoma is the leading cause of irreversible blindness worldwide. This disease causes vision loss when the optic nerve and retinal cells are lost. The etiology of the disease is complex, with a wide range of risk factors. Age, race, family history, myopia, cardiovascular disease, diabetes, abnormal blood rheology, etc. are all risk factors for glaucoma.Read more

NAM: The nemesis of glaucoma struck, helping patients stay away from the “thief” of vision

PROTAC is first showing its edge, SD-36 has excellent anti-tumor effect

On November 11, the team of Chinese-American Wang Shaomeng published a paper titled "A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo” in the scientific journal Cancer Cell, which immediately stirred up thousands of people. Layers of waves have brought PROTAC technology back to people's sight. Shanghai Medicilon Biopharmaceutical Co.,Read more

PROTAC is first showing its edge, SD-36 has excellent anti-tumor effect

LYTAC was born, fighting side-by-side with PROTAC to target non-medicable targets

The advent of PROTAC The advent of PROTAC has brought solutions to targets that traditional small-molecule drugs cannot be made into. After 2017, PROTAC technology has developed rapidly, from the laboratory to the industrial world, starting from Harvard University, Yale University, Arvinas, C4, Kymera Therapeutics have been established to specialize in PROTAC technical drug research,Read more

LYTAC was born, fighting side-by-side with PROTAC to target non-medicable targets

Will vitamin D become a new hope for the prevention and treatment of COVID-19?

The rapid spread of COVID-19 is a public health emergency that has attracted international attention. The clinical situation of COVID-19 is still not fully understood, but it is obviously related to respiratory symptoms, and in some cases it can induce acute multiple organ failure. Respiratory distress syndrome (ARDS), especially in elderly patients with a historyRead more

Will vitamin D become a new hope for the prevention and treatment of COVID-19?

Science Sub-Journal: A new model can predict the injectability of microparticle formulations

Particulate preparation refers to a solid, liquid, semi-solid or gaseous pharmaceutical preparation composed of particles with a certain particle size (micron or nanometer) made by a certain dispersion and embedding technology with a suitable carrier (generally a biodegradable material) It has excellent properties such as improving the stability of the drug, reducing adverse drug reactions,Read more

Science Sub-Journal: A new model can predict the injectability of microparticle formulations

[Nature] New treatment plan for non-small cell lung cancer: targeted degradation of EGFR

Lung cancer is one of the most common malignant tumors in the world, and it has become the first cause of death from malignant tumors in the urban population of our country. Non-small cell lung cancer (NSCLC) includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Compared with small cell carcinoma, cancer cells grow andRead more

[Nature] New treatment plan for non-small cell lung cancer: targeted degradation of EGFR

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