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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Nov 29,2020
Rectal Cancer Early Screening Kit
On November 9, 2020, the National Medical Products Administration (NMPA) approved the registration application for the innovative three types of medical devices for the colorectal cancer early screening product of Nuohui Health, Chang Weiqing, and made it clear in the intended use that the product is suitable for " Screening of 40-74-year-old people at high risk of colorectal cancer".
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Rectal Cancer Early Screening Kit
Nov 27,2020
The latest advances in the development of preclinical HIV vaccines
As researchers continue to find effective ways to fight HIV, but there is still no effective and approved preventive vaccine, vaccines are a key means to prevent the spread of HIV disease. There are 38 million people living with AIDS in the world, and many studies are devoted to developing effective methods to prevent theRead more
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Nov 23,2020
The details of pathological research determine the success or failure of TCR trials
What is TCR? Tissue Cross-Reactivity is an in vitro test that detects the binding of antibody drugs to epitopes on tissues. The purpose is to confirm the binding of the tested antibody to the epitope of the pharmacodynamic target tissue, and to detect whether the antibody binds to the tissue antigen of the non-target site,Read more
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The details of pathological research determine the success or failure of TCR trials
Nov 23,2020
Melatonin has become the "savior" of COVID-19 patients!
Melatonin is a hormone produced by the pineal gland of the brain. People can also use it as a natural or synthetic supplement to promote sleep. Melatonin plays many roles in the body, but the main role is to maintain the circadian rhythm. For humans, the central biological clock is located in the suprachiasmatic nucleusRead more
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Melatonin has become the "savior" of COVID-19 patients!
Nov 17,2020
The strategy of chemical modification to reduce the cardiotoxicity of drug hERG
Reduce fat solubility Through QSAR analysis, Levoin et al. pointed out that the lipid solubility (clogP, clogD or polar surface area PSA) and aromaticity of the molecule are closely related to the hERG inhibitory activity. The fat-soluble aromatic ring in the drug molecule has a π-π hydrophobic interaction with the hERG potassium channel. Reducing theRead more
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The strategy of chemical modification to reduce the cardiotoxicity of drug hERG
Nov 16,2020
Metformin is here again
Among the many hypoglycemic drugs, metformin has been tested for more than 50 years and is the second-generation “star” in hypoglycemic drugs, the first choice for the treatment of “type 2 diabetes” and the entire course, and the first choice for combined treatment of type 2 diabetes. In this way, after the US FDA approvedRead more
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Nov 12,2020
Exercise Became the "Good Medicine" for Cancer Treatment
Exercise affects almost all tissues of the human body. Scientists have found that physical exercise can reduce the risk of cancer and improve the prognosis of cancer patients. People who keep exercising tend to have a lower incidence of cancer, which is proportional to the frequency and intensity of exercise. The metabolic demands of strenuousRead more
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Exercise Became the "Good Medicine" for Cancer Treatment
Nov 04,2020
Nature: BATF3 improves T cell memory response and the efficacy of immunotherapy
The basic leucine zipper transcription factor ATF-like 3 (BATF3) plays a key role in the development of conventional type I dendritic cells, and this type of dendritic cells plays a key role in the cross-presentation of pathogens and CD8+ T cell-mediated It is necessary in immune response such as tumor immunity. During the immune responseRead more
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Nature: BATF3 improves T cell memory response and the efficacy of immunotherapy
Oct 22,2020
Medicine Symposium No. 8-Drug Preclinical Research and Application
Over the years, Medicilon has been actively empowering the upgrading of life sciences and building a platform to promote the integrated development of the biomedical industry. In 2019, starting from the 15th anniversary, a national tour of seminars was launched, and seven pre-clinical research related seminars were successively held. The Medicilon research team shared theRead more
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Medicine Symposium No. 8-Drug Preclinical Research and Application
Oct 21,2020
International teams join forces to accelerate drug design based on the structure of COVID-19!
SARS-CoV-2 is an enveloped single-stranded RNA virus. The viral RNA produces two polyproteins: pp1a and pp1ab through ribosome frameshift. The polyprotein is processed by the papain-like protease (PL pro), which cuts 3 sites to release the non-structural protein nsp1-3 and a 3C-like protease, also known as the main protease (M pro). Cut at 11 sitesRead more
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International teams join forces to accelerate drug design based on the structure of COVID-19!