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Hot information：
Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Dec 03,2020
Application of LC-MS in the Early Stage of Drug Development
Liquid chromatography-mass spectrometry (LC-MS) bioanalysis technology plays a vital role in early drug development and can promote the process of new drug development. Before the introduction of combinatorial chemistry, many drug candidates from natural products and active compounds were extracted and separated, and their chemical structures needed to be analyzed by chemical process test platformsRead more
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Application of LC-MS in the Early Stage of Drug Development
Dec 02,2020
Three Chemicals to Construct a Ulcerative Colitis Model
Ulcerative colitis is a lifelong immune disease of the intestine, also known as ulcerative colitis, and Crohn’s disease is collectively called inflammatory bowel disease. The ideal ulcerative colitis model is of great significance for elucidating the etiology and pathogenesis of the disease and exploring the therapeutic effects of drugs. Ulcerative colitis is an inflammatory processRead more
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Dec 02,2020
Different Bioanalysis Platforms
Bioanalysis is an important part of the drug development process, including pharmacokinetics (PK) and biomarker analysis, which runs through the entire process of drug development from early screening to clinical research to post-marketing monitoring. Pharmacokinetics is usually an important end point of clinical research. Non-clinical and clinical pharmacokinetics not only guide the dosage selection ofRead more
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Different Bioanalysis Platforms
Dec 02,2020
Overview of LBA Test Methods in Bioanalysis
The biological analysis described in this article is to determine the concentration of biological drugs in animal and human body fluids or tissues (this article specifically refers to protein biological drugs, including monoclonal antibodies, cytokines, auxins, fusion proteins, etc.). Most bioanalytical methods are based on immunoassays (Immunoassays), or more broadly called, ligand binding assays (LBA).Read more
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Overview of LBA Test Methods in Bioanalysis
Dec 02,2020
Ligand Binding Test Biological Analysis
In the previous issues, I shared the past and present of the matrix effect of small molecule LC-MS/MS bioanalysis with friends in the circle. This issue returns to the topic of macromolecular bioanalysis. Ligand Binding Assay (LBA) is the most widely used detection method for macromolecular bioanalysis. LBA is based on the equilibrium reaction betweenRead more
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Ligand Binding Test Biological Analysis
Dec 02,2020
Biotechnology Drug Analysis Method：Ligand Binding Test
After ingesting biotechnology drugs, the body will produce different degrees of immune response based on the immunogenicity of the drug. The drug stimulates the body to form specific anti-drug antibodies (ADA) for the immunogenicity of the drug, allergies, autoimmunity and different The pharmacokinetic characteristics of the drug are anti-drug antibody reactions, which can cause variousRead more
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Biotechnology Drug Analysis Method：Ligand Binding Test
Dec 01,2020
Do You Know about Insect Baculovirus Expression System?
Insect Baculovirus Expression Vector System, referred to as IBEVS (Insect Baculovirus Expression Vector System), is one of the four major genetic engineering expression systems. Since it does not have any animal virus fragments that are potentially pathogenic to mammals, the insect baculovirus expression system has been highly valued since its advent. The U.S. Food andRead more
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Do You Know about Insect Baculovirus Expression System?
Dec 01,2020
Introduction of Bac-to-Bac Expression System
Introduction of Bac-to-Bac System The baculovirus-insect cell system is a binary system consisting of two parts. The first part is the baculovirus expression vector, which is an insect virus whose function is obviously to introduce the foreign gene encoding the target protein into the host cell. Another function of baculovirus expression vectors is to provideRead more
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Introduction of Bac-to-Bac Expression System
Dec 01,2020
Baculovirus Expression System (Also Called Insect Cell Expression System)
Insect baculovirus expression system is one of the eukaryotic expression systems. It has the characteristics of high expression level of foreign genes, easy expression of heteromultimeric proteins, and high safety. The recombinantly expressed protein products have correct post-translational modification and biology Activities such as disulfide bond formation, phosphorylation, glycosylation, etc. It is suitable for theRead more
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Baculovirus Expression System (Also Called Insect Cell Expression System)
Dec 01,2020
Baculovirus Expression Vector System
Overview of Protein Expression System In 1983, two sample groups expressed eukaryotic genes in the colon (Harris et al., 1983; Wetzel and Goeddel, 1983). Its genetics, biochemistry and molecular biology have been well understood, so it is the preferred system for the expression of many foreign proteins. The biggest feature of the Escherichia coli expressionRead more
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Baculovirus Expression Vector System
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