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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021

Analysis on the role of drug dissolution test in the determination of human bioavailability

The dissolution rate and extent of solid dosage forms such as tablets, capsules, or granules in a prescribed medium refer to the dissolution rate of the drug.

Analysis on the role of drug dissolution test in the determination of human bioavailability

Humanization of antibody reduces the immunogenicity of antibody drugs

The application of antibodies has a history of hundreds of years. As a disease prevention, diagnosis and treatment agent, antibody drugs have undergone the development of murine antibodies, chimeric antibodies, humanized antibodies and fully humanized antibodies. Because the antibody drug is a kind of foreign protein, it is easy to activate the body's own immuneRead more

Humanization of antibody reduces the immunogenicity of antibody drugs

Analysis of the role of affinity determination in the development of biological drugs

Drugs exert various pharmacological functions in vivo and in vitro by binding to the target, that is, interacting. Affinity (affinity) is a characteristic function of the relative state between candidate molecules, target molecular epitopes and candidate molecule-target molecule conjugates during the reversible reaction process, and can evaluate the strength of the binding between candidate moleculesRead more

Analysis of the role of affinity determination in the development of biological drugs

Analysis on the method of immunogenicity detection of biotechnology drugs

Immunogenicity refers to the nature of drugs that stimulate the body to form specific antibodies or sensitized lymphocytes. In the development of biotechnology drugs, immunogenicity testing is an important task. For patients, immunogenicity will affect the safety and effectiveness of drugs, and even cause life-threatening dangers to patients because of the crossover of anti-drug antibodiesRead more

Analysis on the method of immunogenicity detection of biotechnology drugs

You have never heard of the protein that can "melt" tumors!

Recently, cancer researchers at Vanderbilt discovered a new protein that, when genetically regulated to prevent it from interacting with the genes responsible for cancer, will effectively melt tumors within a few days. This exciting research result was recently published in eLife magazine. protein that can melt tumors You have never heard of the protein thatRead more

You have never heard of the protein that can "melt" tumors!

BioNews| Hoth: Cooperate with Camargo to apply for HT-001 IND

Hoth Therapeutics, Inc. (HOTH) announced that it has entered into an agreement with Camargo PharmaticalServices to collaborate on the preparation of an investigational new drug application (IND) for HT-001 to be submitted to the U.S. Food and Drug Administration (FDA) to initiate the first clinical trial. Camargo collaborates with emerging biopharmaceutical companies to address unmetRead more

BioNews| Hoth: Cooperate with Camargo to apply for HT-001 IND

Analysis of the potential target of lung cancer treatment-aquaporin 4

Lung cancer is one of the most harmful malignant tumors. To explore the pathogenesis of lung cancer and to find new targets for anti-tumor therapy are the hotspots and difficulties of current lung cancer treatment research. Studies have found that aquaporin 4 (AQP4) is highly expressed in lung cancer cells, and knocking down AQP4 canRead more

Analysis of the potential target of lung cancer treatment-aquaporin 4

Analysis on the Role of Cytokine Detection in the Evaluation of Drug Treatment Effect

Cytokines that can regulate the physiological functions of a variety of cells are small molecular protein substances with biological activity secreted by cells. The concentration of cytokines and their receptors can reflect the pathological process of the disease. Through the detection of cytokines and the detection of the level of soluble receptors, the effects ofRead more

Analysis on the Role of Cytokine Detection in the Evaluation of Drug Treatment Effect

Brief Introduction of the Relationship Between GM-CSF Cytokines And Immune diseases

Granulocyte-macrophage colony stimulating factor (GM-CSF) cytokine is an active immune effector factor with a wide range of immune activities in the body. As an immune adjuvant, it can not only promote the maturation of APCs (such as DC and macrophages) and improve its antigen presentation ability, but also play a role in T cell-mediated inflammatoryRead more

Analysis of Three Verification Methods of Biological Sample Analysis

When conducting biomedical research, biological samples have the characteristics of less sampling, low drug concentration, endogenous substances, and individual differences. These factors may affect the determination of biological samples. Therefore, it is necessary to establish appropriate biological sample analysis methods. The verification of these biological analysis methods and the analysis of test samples should complyRead more

Analysis of Three Verification Methods of Biological Sample Analysis

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