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Hot information：
Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Mar 24,2021
Analysis of the Basics of LC-MS Analysis and Analysis of Common Problems
LCMS is an important analysis tool in organic synthesis, and analyzing LCMS spectra is also a basic skill. LC/MS/MS Method Development & Validation Quick turnaround time to speed up the drug development process  Chemical Analytical Center of Medicilon provides general analysis and purification services for the clients. Our experts have rich experience and proficient skillsRead more
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Mar 24,2021
Summary of LC-MS Experience
Liquid chromatography-mass spectrometry technology is also called liquid chromatography-mass spectrometry (LC-MS), which uses liquid chromatography as the separation system and mass spectrometry as the detection system. LC/MS embodies the complementarity of the advantages of chromatography and mass spectrometry. It combines the high separation ability of chromatography for complex samples with the advantages of MS withRead more
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Mar 24,2021
Liquid phase mass spectrometry (LC-MS)-matrix effects in biological analysis
What is the matrix effect? When analyzing drugs in biological samples based on liquid-phase-mass spectrometry (LC-MS) methods, some common extracts of the samples may have an impact on the ionization efficiency of the target compound. This effect can be observed from the response of the instrument, the signal of the compound It is enhanced orRead more
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Liquid phase mass spectrometry (LC-MS)-matrix effects in biological analysis
Mar 24,2021
LC/MS daily maintenance and common failures
1. Clean the ion source Cleaning the ion source is the basic operation of the daily maintenance of LC/MS. Usually, when common problems in ion current chromatograms are encountered, such as peak splitting, unstable baseline, impurity peaks, etc., the first consideration is to clean the ion source. Generally speaking, the frequency of ion source cleaningRead more
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Mar 23,2021
Comparative analysis of LC-MS and LC-MS/MS
LC-MS can obtain total ion chromatograms by collecting mass spectra. Because electrospray is a soft ionization source, there are usually few or no fragments. There are only quasi-molecular ions in the spectrum, so it can only provide molecular weight information of unknown compounds, not structural information. It is difficult to use for qualitative analysis, butRead more
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Mar 23,2021
When ADME and Drug Interaction Studies Need to be Done?
In addition to the need for evidence to prove that the drug is effective, the FDA and other drug regulatory agencies around the world also emphasize that the compounds used for patients are safe. The key elements of a successful IND or equivalent application include a sound pharmacokinetic (PK) profile covering absorption, distribution, metabolism andRead more
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Mar 23,2021
ADME Properties
In the entire process of drug discovery, the optimization of the ADME (absorption, distribution, metabolism and excretion) properties of drug molecules is the most difficult part. The analysis of the properties of ADME plays a key role in the success of drug development. Possible manifestations of poor properties of the candidate drug ADME Increasing theRead more
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Mar 22,2021
Pre-formulation Study of Generic Drug Formulations
The purpose and importance of pre-prescription research The purpose of pre-formulation research is to provide a basis for pre-formulation process design, and to provide a clear mechanism of targeted solutions to problems arising in the research of pre-formulation process.     The quality characteristics of the final product are largely determined by the nature of theRead more
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Pre-formulation Study of Generic Drug Formulations
Mar 22,2021
Basic Knowledge of Pre-Formulation Research for Injections
The rational study of the injection pre-formulation should be based on the quality profile of the target product, the physical and chemical properties of the API, and the compatibility of the API and other excipients. The primary packaging system should be determined according to the storage conditions of the product, and the pharmacokinetic characteristics ofRead more
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Basic Knowledge of Pre-Formulation Research for Injections
Mar 22,2021
Preparations | Detailed Explanation of Preformulation Research
Pre-formulation research has gradually become a routine research project in the design and improvement of dosage forms and preparations, providing a basis for further designing dosage forms and optimizing the formulation process. Medicilon has been offering high quality analytical testing services to the pharmaceutical industry for decades. We offer a wide range of quality controlRead more
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Preparations | Detailed Explanation of Preformulation Research
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