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Hot information：
Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Apr 29,2021
Research on new anti-tumor therapy targeting MCL1 protein in melanoma
Myeloid cell leukemia-1 (myeloidcellleukemia-1, Mcl-1) is a protein that is highly expressed in cervical cancer, liver cancer, lymphoma, lung cancer and other tumor tissues. It can directly regulate cell differentiation and cell cycle. The occurrence and development are closely related. Recombinant protein expression and protein purification research can lay the foundation for studying the biologicalRead more
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Research on new anti-tumor therapy targeting MCL1 protein in melanoma
Apr 28,2021
PDK4 gene can be used as a biomarker for the treatment of prostate cancer
In the development of anti-cancer drugs, many researchers have been paying attention to finding special genetic markers to help identify those patients with prostate cancer that are more prone to worsening and those who can successfully use drug treatment or respond well, trying to find a relationship with prostate cancer. New genetic biomarkers related toRead more
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PDK4 gene can be used as a biomarker for the treatment of prostate cancer
Apr 28,2021
Gateway technology, the technology of constructing insect cell expression vector
In order to improve the high-level and soluble expression of recombinant protein, a protein expression system can be constructed. The baculovirus vector expression system is an efficient eukaryotic expression system that can use baculovirus as a carrier for foreign genes to express foreign proteins by infecting insect cells. Gateway technology is a very convenient vectorRead more
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Gateway technology, the technology of constructing insect cell expression vector
Apr 28,2021
Research found: RBBP8 gene mutation is a key factor in young women suffering from breast cancer
The human CtIP gene, also known as RBBP8, is located on the long arm 11.2 of chromosome 18 and can encode the CtIP protein. There are many studies on CtIP protein, and the relationship between it and tumor pathogenesis is constantly being recognized. Mutations of CtIP protein can be found in a variety of humanRead more
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Research found: RBBP8 gene mutation is a key factor in young women suffering from breast cancer
Apr 28,2021
Lowry method for quantitative detection of protein concentration
The determination of protein content is one of the important indicators for the quality control of biotechnology drugs. Lowry method is a classic method for quantitative determination of protein content, which is widely used and suitable for identifying the purification effect of protein and carrying out activity determination. Lowry method and BCA method can beRead more
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Lowry method for quantitative detection of protein concentration
Apr 28,2021
LYTAC technology, a lysosomal degradation technology
Targeted protein degradation is an emerging direction in the field of drug development. 40% of human genes encode extracellular proteins or membrane proteins. The degradation of cell membrane proteins is usually accomplished through lysosomal pathways. lysosome targeting chimeras lytacs (Lytac technology) are an innovative technology that degrades cell membrane or extracellular proteins, enabling degradation ofRead more
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Apr 27,2021
ADC research and development are normalizing, but Pfizer "quietly” changed hands to others!
On March 18, Pfizer and American biotechnology company Pyxis Oncology (hereinafter referred to as "Pyxis”) jointly announced that the two parties have reached a global licensing agreement for two ADC (antibody-drug conjugate) candidate products, but specific transactions The amount was not disclosed. According to the license agreement, Pfizer will provide Pyxis with worldwide licensing, developmentRead more
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ADC research and development are normalizing, but Pfizer "quietly” changed hands to others!
Apr 27,2021
The main points of clinical use of 8 ADC drugs
Antibody-Drug Conjugate (ADC) is a class of targeted biological agents that conjugate target-specific monoclonal antibodies to highly lethal cytotoxic drugs through a specific connector.Small molecule cytotoxic drugs can be efficiently delivered to target tumor cells by using monoclonal antibodies as the carrier.
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The main points of clinical use of 8 ADC drugs
Apr 26,2021
The first CD19 targeting ADC drug is approved, who is leading the ADC market?
A few days ago,ADC Therapeutics SA announced that the FDA has approved its antibody-conjugated drug Zynlonta (loncastuximab tesirine-LPYL) for the treatment of adult patients with relapsed or refractory large B-cell lymphoma (R/ R DLBCL) who have previously received 2-line or more systemic therapy. Loncastuximab tesirine (Lonca, formerly known as ADCT-402) is an antibody-conjugated drug (ADC)Read more
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The first CD19 targeting ADC drug is approved, who is leading the ADC market?
Apr 26,2021
Something you must know about the yeast two-hybrid system
Yeast two-hybrid Yeast two-hybrid, proposed by Fields in 1989, is primarily used to analyze the gene system for protein-protein interactions in yeast and is a genetic method for the module structure of transcription factors. The yeast two-hybrid system was developed in eukaryotic model yeast to study protein interactions in living cells, and weak, transient interactionsRead more
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Something you must know about the yeast two-hybrid system
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