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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Apr 05,2016
Programming Language Automates Generation of Plug and Play DNA
    From the synthetic biologist's point of view, living cells are biological computers, and the ultimate code isn't binary, but tertiary, a stream of A's, T's, C's, and G's. But tinkering with this code, so as to generate alternative or supplementary biological circuitry, has been tedious and time-intensive, requiring the manual assembly of parts and theRead more
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Programming Language Automates Generation of Plug and Play DNA
Apr 05,2016
3D DNA Images for Nanoscale Design
    The general chemical structure of the DNA helix was described by James Watson and Francis Crick in 1953. Over the years that followed, scientists intensely studied the molecular structure of DNA to understand its behavior in vivo and to exploit its unique properties for nanotechnology purposes.     Now, an international team of scientists working at theRead more
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3D DNA Images for Nanoscale Design
Apr 04,2016
Researchers Use New Technology to Sequence Mosquito Sex Chromosome
    The genome of the malaria-carrying mosquito was sequenced at least a decade ago, and current mosquito-control efforts emphasize genetic strategies for biasing mosquito populations toward males, particularly infertile males. So, you would think that we would have figured out the mosquito's Y chromosome. But we hadn't—at least not until the recently announced success of aRead more
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Researchers Use New Technology to Sequence Mosquito Sex Chromosome
Apr 04,2016
A Biomimetic Bridge to Precision Medicine
The ability to recapitulate closely the cellular environment in which a new drug compound will be exposed once inside the body is the goal most scientists strive toward during the drug development process. However, creating 3D cellular systems has proven costly and cumbersome for most research laboratories.  
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A Biomimetic Bridge to Precision Medicine
Apr 01,2016
Prostate Cancer Researchers Find New Target in Battle against Resistance
    In a collaborative study, led by scientists at the University of California Davis, researchers report that by suppressing the orphan nuclear receptor protein ROR-γ with small-molecule compounds they could reduce androgen receptor (AR) levels in castration-resistant prostate cancer and stop tumor growth.       This unique approach does not look to target the AR directly, whichRead more
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Prostate Cancer Researchers Find New Target in Battle against Resistance
Apr 01,2016
Novel Drug Combinations Aim at Better Tuberculosis Therapy Outcomes
    Scientists at UCLA and Shanghai Jiao Tong University say they have made an important step toward a substantially faster and more effective treatment for tuberculosis, which infects some 10 million people and causes 1.5 million deaths each year.       The team's research ("Output-Driven Feedback System Control Platform Optimizes Combinatorial Therapy of Tuberculosis Using a MacrophageRead more
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Novel Drug Combinations Aim at Better Tuberculosis Therapy Outcomes
Mar 31,2016
New Spin on Biomolecular Tags Lets MRI Catch Metabolic Wobbles
    In principle, magnetic resonance imaging (MRI) could be used to track disease-related biomolecular processes. In practice, magnetic resonance signals die out too quickly. Also, these signals are detectable only with incredibly expensive equipment. The necessary devices, called hyperpolarizers, are commercially available, but they cost as much as $3 million each.     Yet magnetic resonance can beRead more
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New Spin on Biomolecular Tags Lets MRI Catch Metabolic Wobbles
Mar 31,2016
Tissue Regeneration Promoted through Gene Suppression
    Having a greater understanding of how certain tissues regenerate after injury would be extraordinarily useful in treating various diseases. Many animals have the capacity to regenerate entire appendages, such as tails in lizards and arms in starfish, yet mammals have all but lost the capacity to regenerate body parts extensively.     Now, scientists at the Children’sRead more
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Mar 30,2016
Designing Drugs to Combat Dangerous C difficile Infections
    Infections with Clostridium difficile have become a critical medical issue in hospitals and long-term care facilities. This bacterium causes diarrhea and life-threatening inflammation of the colon by producing toxins that kill the endothelial cells that form the lining of the gut.     Although a natural inhibitor of these toxins, called InsP6, works in the test tube,Read more
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Designing Drugs to Combat Dangerous C difficile Infections
Mar 30,2016
Individual Cells in Four Cell Embryos Chase Different Fates
    Somewhere along embryonic development, individual cells begin following divergent paths of gene expression. But exactly where cellular fates start to point in different directions has been unclear. Presumably, the earliest branching occurs before implantation, as embryos at the implantation stage already contain at least two kinds of cells—cells that will give rise to the bodyRead more
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Individual Cells in Four Cell Embryos Chase Different Fates