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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Apr 20,2016
Flawed Mitochondrial DNA Could Undermine Stem Cell Therapies
    Mutations in our mitochondrial DNA tend to be inconspicuous, but they can become more prevalent as we age. They can even vary in frequency from cell to cell. Naturally, some cells will be relatively compromised because they happen to have a higher percentage of mutated mitochondrial DNA. Such cells make a poor basis for stem cellRead more
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Apr 19,2016
Genomic Makeup of Colorectal Cancers Predicts Immune System Ability to Fight Tumors
Colorectal cancers heavily bedecked with tumor-related proteins called neoantigens are likely to be permeated with disease-fighting white blood cells, researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study. Because such an influx of white blood cells often signifies an immune system attack on cancer, the discovery will sharpen research into therapies that make tumors more vulnerable to such an attack.
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Genomic Makeup of Colorectal Cancers Predicts Immune System Ability to Fight Tumors
Apr 19,2016
Signal Loop Pulls Healthy Cells into Cancer Echo Chamber
    In the cellular media environment, some of the most pernicious messaging occurs within tumors, which form a kind of echo chamber that amplifies molecular interactions. These interactions, which support the growth and spread of cancer, occur not only between genetically diverse cancer cells, but also between cancer cells and healthy cells.     That healthy cells shouldRead more
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Signal Loop Pulls Healthy Cells into Cancer Echo Chamber
Apr 18,2016
Spotting DNA Repair Genes Gone Awry
    Researchers led by Ludwig Cancer Research scientist Richard Kolodner have developed a new technique for determining out the genes responsible for helping repair DNA damage that, if left unchecked, can lead to certain cancers.     Genome instability suppressing (GIS) genes play an important role in correcting DNA damage involving the improper copying or reshuffling of largeRead more
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Spotting DNA Repair Genes Gone Awry
Apr 18,2016
Chinese Scientists Test Genetic Modification of Human Embryos with CRISPR
    In April of 2015, Chinese researchers announced to the world that they had used the new genome-editing technology CRISPR/Cas9 on human preimplantation embryos to modify the HBB gene, mutations of which have been implicated in the disease β-thalassemia. The news had sparked a media firestorm and eventually led scientists from across the globe to discussRead more
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Apr 15,2016
More Evidence that Coffee Protects Against Nonalcoholic Liver Disease
    Evidence is mounting that drinking coffee may be valuable to help protect against non-alcoholic fatty liver disease, a potentially deadly disorder for which there currently are no medical treatments.     Non-alcoholic fatty liver disease (NAFLD) is a buildup of extra fat cells in the liver. It is estimated that 20 percent of adults and 10 percentRead more
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Apr 15,2016
Antibiotics Do Not Promote Swapping of Resistance Genes
    Researchers have shown that, outside of a few specific examples, antibiotics do not promote the spread of bacterial antibiotic resistance through genetic swapping, as previously assumed.     While the overuse of antibiotics is undeniably at the heart of the growing global crisis, new research published online April 11 in Nature Microbiology suggests differential birth and deathRead more
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Antibiotics Do Not Promote Swapping of Resistance Genes
Apr 14,2016
Newly Discovered Proteins May Protect Against Aging Illnesses
    A group of six newly discovered proteins may help to divulge secrets of how we age, potentially unlocking new insights into diabetes, Alzheimer's, cancer, and other aging-related diseases.       The proteins appear to play several roles in our bodies' cells, from decreasing the amount of damaging free radicals and controlling the rate at which cellsRead more
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Apr 14,2016
Zika Tied to Brain Disorder Similar to MS
    The Zika virus may be associated with an autoimmune disorder that attacks the brain's myelin similar to multiple sclerosis, according to a small study that is being released April 10 and will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.     "Though our study isRead more
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Zika Tied to Brain Disorder Similar to MS
Apr 13,2016
Scientists Find Novel Metabolic Twist That Drives Cancer Survival
    Being attached to the extracellular matrix (ECM) provides cells with numerous advantages for survival, for instance, receiving much needed growth stimuli. However, for malignant cells to function, they must overcome their anchorage-dependent growth—a scenario that is associated with increased production of reactive oxygen species (ROS) and altered glucose metabolism.       Scientists at the Children's MedicalRead more
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Scientists Find Novel Metabolic Twist That Drives Cancer Survival