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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
May 04,2016
HIV Particles Used as Tool to Capture Native Protein Complexes
Protein purification has been the cornerstone of laboratory research for decades, and in that time, scientists have funneled considerable effort and finances into isolating protein complexes under native conditions. Classical purification techniques require the use of cell lysis chemicals that often disassociate the interactions between complex protein molecules.   Now Belgian scientists from the FlandersRead more
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May 03,2016
Different Diseases with Similar Genetic Properties Open New Drug Research Avenues
    The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets, according to the collaboration between the Perelman School of Medicine at the University of Pennsylvania, the University of Arizona Health Sciences, Vanderbilt University, and others. TheRead more
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May 03,2016
MicroRNA Pathway Could Be New Avenues For Leukemia Treatment
    Increasingly, cancer researchers are discovering novel biological pathways that regulate the expression of various genes that are often strongly associated with tumorigenesis. These new molecular mechanisms represent important potential therapeutic targets for aggressive and difficult-to-treat cancers. In particular, microRNAs (miRNAs)—small, noncoding genetic material that regulates gene expression—have steadily become implicated in the progression of someRead more
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MicroRNA Pathway Could Be New Avenues For Leukemia Treatment
May 02,2016
Potential Good Fat Biomarker
Brown fat cells can burn fat to generate heat. University of Bonn researchers have discovered a new method to measure the activity of brown fat cells in humans and mice. The researchers showed that microRNA-92a can be used as an indirect measure for the activity of energy consuming brown fat cells. They showed that aRead more
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May 02,2016
Genomic Study Sheds Light on Evolution of Multicellularity
It's just a clump of 16 cells, but it tells us a lot about an otherwise lost chapter in the evolution of multicellularity. The cells, which belong to a species of green algae called Gonium pectorale, contain genes that clarify how at least one unicellular-to-multicellular transition occurred among a group of closely related organisms, aRead more
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Genomic Study Sheds Light on Evolution of Multicellularity
Apr 29,2016
Retroviral DNA Findings May Lead to Better Therapies for HIV Infection
    When retroviruses such as HIV infect a cell, they first make a copy of their RNA genome in the form of DNA. The relatively short viral DNA strand then moves to the cell nucleus, where it inserts itself into the host cell’s DNA.     Scientists at The Ohio State University Comprehensive Cancer Center–Arthur G. James CancerRead more
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Apr 29,2016
New CRISPR System Targets Both DNA and RNA
    With a staggering number of papers published in the past several years involving the characterization and use of the CRISPR/Cas9 gene editing system, it is surprising that researchers are still finding new features of the versatile molecular scissor enzyme.  Researchers from the Max Planck Institute for Infection Biology in Berlin, the Umeå University in SwedenRead more
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New CRISPR System Targets Both DNA and RNA
Apr 28,2016
Driver of Deadly Brain Cancer Discovered, Potential New Drug Target
Glioblastoma multiforme (GBM) is one of the most common, aggressive, and deadly brain cancers—often difficult to remove surgically and to develop resistance to radiation and chemotherapy. A team of researchers at the University of Ottawa believes they have found a major driving force in tumor formation that could lead to developing novel therapies to treat this intractable cancer.
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Driver of Deadly Brain Cancer Discovered, Potential New Drug Target
Apr 28,2016
Fusion Protein Technique Shows Promise for Safer Cell Targeted Therapeutics
    A new strategy for engineering protein fusions to make specific cell-targeted drugs without side effects could enable a safer, more potent class of protein drugs, according to scientists at the Wyss Institute for Biologically Inspired Engineering. They say they designed a better variant of the widely used drug erythropoietin (EPO), showing how rational design canRead more
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Fusion Protein Technique Shows Promise for Safer Cell Targeted Therapeutics
Apr 27,2016
Unique Mouse Model Developed to Study ALS
    Scientists at University of Florida Health say they have developed a unique mouse model that will allow researchers around the world to better study the genetic origins and potential treatments for a neurodegenerative brain disease that causes amyotrophic lateral sclerosis, often referred to as ALS or Lou Gehrig's disease, and frontotemporal dementia (FTD).     The modelRead more
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Unique Mouse Model Developed to Study ALS