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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
May 18,2016
Transcriptional Activation Mechanisms Revealed by Computer Simulations
The discrete regulatory mechanisms that control gene expression are critical for proper protein production and overall cell viability. Yet, in numerous cases, errors within the genetic code lead to faulty manufacturing of proteins—resulting in genetic diseases like cystic fibrosis and hemophilia. Transcription factors, which moderate gene expression, bind to the start of a gene sequenceRead more
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Transcriptional Activation Mechanisms Revealed by Computer Simulations
May 17,2016
Genetically Engineered Pigs May Fly as Cancer Models
    We may soon hear cancer researchers say, "That'll do pig, that'll do.” To date, cancer researchers have contented themselves with using rodents in the laboratory, in part because of the additional costs of maintaining animals so large and as long-lived as pigs. Yet, with access to the tools of precision genetics, cancer researchers may beRead more
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May 17,2016
Histone Mutation Deranges DNA Methylation to Cause Cancer
    They have been called oncohistones, the mutated histones that are known to accompany certain pediatric cancers. Despite their suggestive moniker, oncohistones have kept their oncogenic secrets. For example, it has been unclear whether oncohistones are able to cause cancer on their own, or whether they need to act in concert with additional DNA mutations, thatRead more
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May 16,2016
We Do Not Need No Stinking Mitochondria
    The organelle that produces a significant portion of energy for eukaryotic cells would seemingly be indispensable, yet over the years, a number of organisms have been discovered that challenge that biological pretense. However, these so-called amitochondrial species may lack a defined organelle, but they still retain some residual functions of their mitochondria-containing brethren. Even theRead more
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We Do Not Need No Stinking Mitochondria
May 16,2016
Hard Proof of Zika Brain Attack in Multiple Animal Models
    Zika virus infections have been tracked from a pregnant mouse's bloodstream, across the placental membrane, and into the brains of fetal mice, where damage to neurons was observed. These findings, which appeared in two separate articles—one in Cell and one in Nature—were complemented by a study that indicated fetal mice infected with Zika developed microcephaly.Read more
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Hard Proof of Zika Brain Attack in Multiple Animal Models
May 13,2016
Frankenstein Proteins Stitched Together by Scientists
    Unlike Victor Frankenstein, who betrayed Promethean ambition when he sewed together his infamous creature, today's biochemists are relatively modest. Rather than defy nature, they emulate it. For example, at the University of North Carolina (UNC), researchers have taken inspiration from natural evolutionary mechanisms to develop a technique called SEWING—Structure Extension With Native-substructure Graphs. SEWING isRead more
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Frankenstein Proteins Stitched Together by Scientists
May 13,2016
Brain Imaging Links Decline of Alzheimer to Tau Protein
    A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer's disease. While much Alzheimer's research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recentlyRead more
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Brain Imaging Links Decline of Alzheimer to Tau Protein
May 12,2016
Personalized Virtual Heart Predicts the Risk of Sudden Cardiac Death
    When electrical waves in the heart run amok in a condition called arrhythmia, sudden death can occur. To save the life of a patient at risk, doctors currently implant a small defibrillator to sense the onset of arrhythmia and jolt the heart back to a normal rhythm. But a thorny question remains: How should doctorsRead more
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May 12,2016
New Insights into Rare Cancer Uncovered in Large Genome Analysis Study
    Research teams from 39 institutions around the world collected and analyzed 91 samples of adrenocortical carcinoma (ACC)—hoping to improve our understanding about one of the rarest, and lethal, types of cancer. This comprehensive analysis was performed as part of The Cancer Genome Atlas (TCGA) Research Network.
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New Insights into Rare Cancer Uncovered in Large Genome Analysis Study
May 11,2016
Bipolar Disorder Has Genetic Links to Autism
    A new study suggests there may be an overlap between rare genetic variations linked to bipolar disorder (BD) and those implicated in schizophrenia and autism.     Research from scientists at the University of Iowa (UI) Carver College of Medicine, Johns Hopkins School of Medicine, Cold Spring Harbor Laboratory, and other institutions suggests that there may beRead more
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Bipolar Disorder Has Genetic Links to Autism