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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jul 01,2016
CRISPR Exposes Genomic Evolutionary Mechanisms
    The continued evolution of any organism is based upon the plasticity of its genome and the dissemination of genetic modifications—mutations—onto subsequent generations. Now scientists at the Karlsruhe Institute of Technology (KIT) in Germany have been able to detect an important mechanism in the evolution of plant genomes using the model organism Arabidopsis thaliana. Employing the CRISPR-CasRead more
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CRISPR Exposes Genomic Evolutionary Mechanisms
Jun 30,2016
West Nile Virus Sparks Synaptic Inflammation Leading to Memory Loss
    Scientists at the University of Colorado Anschutz Medical Campus say they have discovered how the most severe forms of West Nile virus (WNV) cause memory loss and mood disorders, opening the door to potential new treatments for the mosquito-borne illness. Their study ("A Complement–Microglial Axis Drives Synapse Loss During Virus-Induced Memory Impairment”), published in Nature,Read more
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Jun 30,2016
Targeting Glycans Puts Icing on T Cell Therapy
    Making a good thing even better, scientists based at the University of Pennsylvania School of Medicine have genetically modified T cells that show promise against solid tumors, not just blood cancers. To date, T cells modified to express chimeric antigen receptors (CARs) have been too indiscriminate to use against solid tumors. The CAR T cellsRead more
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Targeting Glycans Puts Icing on T Cell Therapy
Jun 29,2016
Researchers Explore Epigenetic Influences of Chronic Pain
    Chronic pain is one of the most prevalent, disabling and expensive public health crises in the United States.  It affects more than 100 million Americans, with annual costs estimated at $635 billion, says a 2014 report from the American Pain Society.     Despite the huge societal impact of chronic pain, present treatment options are limited to nonsteroidal anti-inflammatoryRead more
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Jun 29,2016
Itchy Inflammation of Mosquito Bites Helps Viruses Replicate
    Mosquito bite sites are not just itchy, irritating nuisances – they also make viral infections spread by the insects far worse, new research has found.     The raised red welts and searing itch that result from the bite of insidious mosquitos may, according to recently published data, help any viruses the insect is carrying pass onRead more
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Jun 28,2016
Self Assembling Protein Icosahedral Shell Designed
    The same 20-sided solid that was morphed into geodesic domes in the past centurymay be the shape of things to come in synthetic biology.     Scientists at the University of Washington, Institute of Protein Design have designed and produced a self-assembling protein shell shaped like an icosahedron, similar to those that encapsulate viruses. The researchers believeRead more
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Self Assembling Protein Icosahedral Shell Designed
Jun 28,2016
Molecular Map Marks the Spot for Zinc
The controlled uptake and use of trace metals such as zinc are vital to many molecular mechanisms within the body. Moreover, mapping the molecular structure where medicinal compounds function is a crucial step toward drug discovery against deadly diseases. Now, researchers at Michigan State University (MSU) have taken a vital step forward by providing aRead more
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Molecular Map Marks the Spot for Zinc
Jun 27,2016
Obesity of Pregnant Women May Affect Future Generations
    If mom tips the weight scales, she may also tip her offspring, and subsequent generations, toward metabolic dysfunction. And mom's influence may be conveyed through the maternal germline, which means that future generations could consume healthy diets and still be predisposed to obesity-related conditions such as type 2 Diabetes and heart disease.     New research showsRead more
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Obesity of Pregnant Women May Affect Future Generations
Jun 27,2016
CRISPR Screen Identifies Potential Drug Target for Mosquito Borne Virus
    Flavivirus represent a medically important genus of pathological viruses that are typically transmitted through the bite from an infected arthropod (mosquito or tick). This genus includes the viruses that cause yellow fever—for which the group gets its name, as flavus means yellow in Latin—dengue, West Nile Virus, Zika, and tick-borne encephalitis. Flaviviruses are genetically comprisedRead more
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CRISPR Screen Identifies Potential Drug Target for Mosquito Borne Virus
Jun 24,2016
Unlocking Innate Immunity Gut Reaction toward Inflammatory Bowel Disease
    Evidence supporting the vital role the innate immune system has among inflammatory diseases continues to grow. Now, an international team of researchers believes they have unlocked secrets of the ancient immune system, a significant scientific advance that could help scientists and clinicians in the global fight against disease. The research team identified interactions between immuneRead more
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Unlocking Innate Immunity Gut Reaction toward Inflammatory Bowel Disease