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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Sep 02,2016
Bringing Artificial Enzymes Closer to Nature
    Industrial chemistry and biological chemistry don't always mix well within living cells. For example, olefin metathesis, a reaction type that inspired research honored by the 2005 Nobel Prize in Chemistry, relies on organometallic catalysts that tend to fare poorly in aqueous solutions or cellular-like environments. Nonetheless, such catalysts have been brought closer to nature. TheyRead more
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Bringing Artificial Enzymes Closer to Nature
Sep 02,2016
High Throughput Screening in Drug Discovery Services
High Throughput Screening (HTS) is a popular approach to target validation as it allows the assaying of a large number of potential biological modulators against a chosen set of defined targets. For more than 12 years, Medicilon has been providing chemical compounds to pharmaceutical and biotechnology companies for drug discovery. Our screening capacity currently allowsRead more
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High Throughput Screening in Drug Discovery Services
Sep 01,2016
DNA Can Be Edited Without Being Cut
    Scientists at Kobe University in Japan have developed a new gene-editing technique by combining elements of a bacterial immune system, CRISPR/Cas9, and a vertebrate immune system, AID, or activation-induced cytidine deaminase. The new technique, called Target-AID, preserves the CRISPR/Cas9's DNA-targeting machinery but dispenses with its DNA-cleaving functionality. In place of DNA cleavage, Target-AID employs theRead more
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DNA Can Be Edited Without Being Cut
Sep 01,2016
New Technique Purifies Liver Cells Obtained from iPSCs
 A team of scientists reports that it has found a better way to purify liver cells made from induced pluripotent stem cells (iPSCs). The study ("Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes”), published in Stem Cell Reports, is expected to aid work on liver disease for the NationalRead more
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New Technique Purifies Liver Cells Obtained from iPSCs
Aug 31,2016
Multipartite Virus Found for First Time in Animals
    Multipartite or multicomponent viruses—which stow parts of their infectious payloads in separate particles—have been known to infect plants and fungi. Multipartite-style infections even afflict computer systems. And now, for the first time, the multipartite approach to infection has been found to affect animals. Specifically, a multipartite virus has been found in mosquitoes.     The revelation comesRead more
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Aug 31,2016
Force Triggers Gene Expression by Stretching Chromatin
    How genes in our DNA are expressed into traits within a cell is a complicated mystery with many players, the main suspects being chemical. However, scientists at the University of Illinois and collaborators in China say they have demonstrated that external mechanical force can directly regulate gene expression. The study also identified the pathway thatRead more
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Force Triggers Gene Expression by Stretching Chromatin
Aug 30,2016
Marijuana Compound May Improve Night Vision
The most strident supporters of cannabis often expound the plant’s beneficial properties, from the ephemeral mystical to the empirically medicinal. In recent years, opinions on the drug have begun to soften, and hypothesis-driven research continues to increase, with the intent of separating factual data from anecdotes. Now, a collection of investigators led by scientists atRead more
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Aug 30,2016
Lose the Weight, Escape the 8 Cancers
    New evidence published today by the International Agency for Cancer on Research (IARC), part of World Health Organization, provides even more of a reason to maintain a healthy weight as we age. The international team of researchers has identified eight additional types of cancer linked to excess weight and obesity: stomach, liver, gallbladder, pancreas, ovary,Read more
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Lose the Weight, Escape the 8 Cancers
Aug 30,2016
Medicilon's Preclinical Toxicology Studies Services
Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. Do you know what is preclinical toxicology studies? Medicilon has successfully established a wide range of inRead more
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Medicilon's Preclinical Toxicology Studies Services
Aug 29,2016
Blame the Genes for Coffee Addiction
    Some people cannot start the day without a piping hot cup of coffee. Now, scientists have identified a gene that may explain why some people drink more coffee than others.  People with a variation in the PDSS2 gene tend to drink fewer cups of coffee, according to the study (“Non-additive Genome-wide Association Scan Reveals aRead more
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